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Mechanosensitive Ion Channel Piezo1 Activated by Matrix Stiffness Regulates Oxidative Stress-Induced Senescence and Apoptosis in Human Intervertebral Disc Degeneration

Mechanical stimulation plays a crucial part in the development of intervertebral disc degeneration (IDD). Extracellular matrix (ECM) stiffness, which is a crucial mechanical microenvironment of the nucleus pulposus (NP) tissue, contributes to the pathogenesis of IDD. The mechanosensitive ion channel...

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Detalles Bibliográficos
Autores principales:	Wang, Bingjin, Ke, Wencan, Wang, Kun, Li, Gaocai, Ma, Liang, Lu, Saideng, Xiang, Qian, Liao, Zhiwei, Luo, Rongjin, Song, Yu, Hua, Wenbin, Wu, Xinghuo, Zhang, Yukun, Zeng, Xianlin, Yang, Cao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7889339/ https://www.ncbi.nlm.nih.gov/pubmed/33628392 http://dx.doi.org/10.1155/2021/8884922

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