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Ecotypic Variations Affected the Biological Effectiveness of Thymus daenensis Celak Essential Oil

Thymus (Lamiaceae) is famous for its pharmacological properties. Thymus daenensis Celak (Avishan-e-denaee in Persian) is an endemic Thymus species in Iran and is traditionally used for its digestive, carminative, antitussive, antispasmodic, and expectorant attributes in folk medicine. Ecotypic oils...

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Autores principales: Elahian, Fatemeh, Garshasbi, Maryam, Mehri Asiabar, Zahra, Gholamian Dehkordi, Neda, Yazdinezhad, Alireza, Mirzaei, Seyed Abbas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7889342/
https://www.ncbi.nlm.nih.gov/pubmed/33628312
http://dx.doi.org/10.1155/2021/6686558
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author Elahian, Fatemeh
Garshasbi, Maryam
Mehri Asiabar, Zahra
Gholamian Dehkordi, Neda
Yazdinezhad, Alireza
Mirzaei, Seyed Abbas
author_facet Elahian, Fatemeh
Garshasbi, Maryam
Mehri Asiabar, Zahra
Gholamian Dehkordi, Neda
Yazdinezhad, Alireza
Mirzaei, Seyed Abbas
author_sort Elahian, Fatemeh
collection PubMed
description Thymus (Lamiaceae) is famous for its pharmacological properties. Thymus daenensis Celak (Avishan-e-denaee in Persian) is an endemic Thymus species in Iran and is traditionally used for its digestive, carminative, antitussive, antispasmodic, and expectorant attributes in folk medicine. Ecotypic oils were extracted and analyzed with the GC-MS. Their biological properties in terms of antimicrobial, antioxidant, and antigenotoxic activities were evaluated using the minimal inhibitory concentration, minimal bactericidal concentration, and DPPH, β-carotene, and comet assays. The GC-MS results for Thymus daenensis Celak oils revealed thymol (73.86%) and carvacrol (51.89%) as the most abundant components. Due to the results, reasonable bactericidal activity values range from 0.14 to 5.00 mg/ml, and fungicidal activity ranges from 0.17 to 0.58 mg/ml. The necessary oil free radical scavenging capacity (0.41–1.79 mg/ml), bleaching inhibitory activity (0.01–1.06 mg/ml), and genoprotective potential (1.04–7.78 mg/ml) indicated the dose-dependent activity. The results suggest that Thymus daenensis is an important antibacterial and antifungal bioresource. Additionally, the antioxidant and radical scavenging capacity suggests this species has a role as a natural preservative in oxidative diseases and in the prevention of food spoilage.
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spelling pubmed-78893422021-02-23 Ecotypic Variations Affected the Biological Effectiveness of Thymus daenensis Celak Essential Oil Elahian, Fatemeh Garshasbi, Maryam Mehri Asiabar, Zahra Gholamian Dehkordi, Neda Yazdinezhad, Alireza Mirzaei, Seyed Abbas Evid Based Complement Alternat Med Research Article Thymus (Lamiaceae) is famous for its pharmacological properties. Thymus daenensis Celak (Avishan-e-denaee in Persian) is an endemic Thymus species in Iran and is traditionally used for its digestive, carminative, antitussive, antispasmodic, and expectorant attributes in folk medicine. Ecotypic oils were extracted and analyzed with the GC-MS. Their biological properties in terms of antimicrobial, antioxidant, and antigenotoxic activities were evaluated using the minimal inhibitory concentration, minimal bactericidal concentration, and DPPH, β-carotene, and comet assays. The GC-MS results for Thymus daenensis Celak oils revealed thymol (73.86%) and carvacrol (51.89%) as the most abundant components. Due to the results, reasonable bactericidal activity values range from 0.14 to 5.00 mg/ml, and fungicidal activity ranges from 0.17 to 0.58 mg/ml. The necessary oil free radical scavenging capacity (0.41–1.79 mg/ml), bleaching inhibitory activity (0.01–1.06 mg/ml), and genoprotective potential (1.04–7.78 mg/ml) indicated the dose-dependent activity. The results suggest that Thymus daenensis is an important antibacterial and antifungal bioresource. Additionally, the antioxidant and radical scavenging capacity suggests this species has a role as a natural preservative in oxidative diseases and in the prevention of food spoilage. Hindawi 2021-02-09 /pmc/articles/PMC7889342/ /pubmed/33628312 http://dx.doi.org/10.1155/2021/6686558 Text en Copyright © 2021 Fatemeh Elahian et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Elahian, Fatemeh
Garshasbi, Maryam
Mehri Asiabar, Zahra
Gholamian Dehkordi, Neda
Yazdinezhad, Alireza
Mirzaei, Seyed Abbas
Ecotypic Variations Affected the Biological Effectiveness of Thymus daenensis Celak Essential Oil
title Ecotypic Variations Affected the Biological Effectiveness of Thymus daenensis Celak Essential Oil
title_full Ecotypic Variations Affected the Biological Effectiveness of Thymus daenensis Celak Essential Oil
title_fullStr Ecotypic Variations Affected the Biological Effectiveness of Thymus daenensis Celak Essential Oil
title_full_unstemmed Ecotypic Variations Affected the Biological Effectiveness of Thymus daenensis Celak Essential Oil
title_short Ecotypic Variations Affected the Biological Effectiveness of Thymus daenensis Celak Essential Oil
title_sort ecotypic variations affected the biological effectiveness of thymus daenensis celak essential oil
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7889342/
https://www.ncbi.nlm.nih.gov/pubmed/33628312
http://dx.doi.org/10.1155/2021/6686558
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