Interactions between anti-EGFR therapies and cytotoxic chemotherapy in oesophageal squamous cell carcinoma: why clinical trials might have failed and how they could succeed

PURPOSE: Oesophageal squamous cell carcinoma (ESCC) has a poor prognosis. Advanced tumours are treated with fluoropyrimidine/platinum chemotherapy followed by irinotecan or taxane monotherapy, but resistance is common and new treatments are needed. Approximately 20% of ESCCs carry copy number gain (...

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Detalles Bibliográficos
Autores principales: Meemanage, Madusha, Spender, Lindsay C., Collinson, Diane, Iannetta, Joanna, Challapalli, Pranavi, Turbitt, Julie, Clark, Caroline, Baxter, Mark, Murray, Graeme, Walsh, Shaun, Miedzybrodzka, Zofia, Petty, Russell D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7889538/
https://www.ncbi.nlm.nih.gov/pubmed/33169187
http://dx.doi.org/10.1007/s00280-020-04187-w

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