Ectopic expression of pericentric HSATII RNA results in nuclear RNA accumulation, MeCP2 recruitment, and cell division defects

Within the pericentric regions of human chromosomes reside large arrays of tandemly repeated satellite sequences. Expression of the human pericentric satellite HSATII is prevented by extensive heterochromatin silencing in normal cells, yet in many cancer cells, HSATII RNA is aberrantly expressed and...

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Detalles Bibliográficos
Autores principales: Landers, Catherine C., Rabeler, Christina A., Ferrari, Emily K., D’Alessandro, Lia R., Kang, Diana D., Malisa, Jessica, Bashir, Safia M., Carone, Dawn M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7889552/
https://www.ncbi.nlm.nih.gov/pubmed/33585981
http://dx.doi.org/10.1007/s00412-021-00753-0

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