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Cerebral arterial architectonics and CFD simulation in mice with type 1 diabetes mellitus of different duration
Type 1 diabetes is a chronic autoimmune disease that affects tens of millions of people. Diabetes mellitus is one of the strongest factors in the development of cerebrovascular diseases. In this study we used NOD.CB17 Prkdcscid mice and the pharmacological model of type 1 diabetes mellitus of differ...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7889636/ https://www.ncbi.nlm.nih.gov/pubmed/33597584 http://dx.doi.org/10.1038/s41598-021-83484-7 |
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author | Yankova, Galina Tur, Darya Parshin, Daniil Cherevko, Alexander Akulov, Andrey |
author_facet | Yankova, Galina Tur, Darya Parshin, Daniil Cherevko, Alexander Akulov, Andrey |
author_sort | Yankova, Galina |
collection | PubMed |
description | Type 1 diabetes is a chronic autoimmune disease that affects tens of millions of people. Diabetes mellitus is one of the strongest factors in the development of cerebrovascular diseases. In this study we used NOD.CB17 Prkdcscid mice and the pharmacological model of type 1 diabetes mellitus of different duration to study changes in the cerebral vasculature. We used two combined approaches using magnetic resonance angiography both steady and transient CFD blood flow modeling. We identified the influence of type 1 diabetes on the architectonics and hemodynamics of the large blood vessels of the brain as the disease progresses. For the first time, we detected a statistically significant change in angioarchitectonics (the angles between the vessels of the circle of Willis, cross-sections areas of vessels) and hemodynamic (maximum blood flow rate, hydraulic resistance) in animals with diabetes duration of 2 months, that is manifested by the development of asymmetry of cerebral blood flow. The result shows the negative effect of diabetes on cerebral circulation as well as the practicability of CFD modeling. This may be of extensive interest, in pharmacological and preclinical studies. |
format | Online Article Text |
id | pubmed-7889636 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-78896362021-02-22 Cerebral arterial architectonics and CFD simulation in mice with type 1 diabetes mellitus of different duration Yankova, Galina Tur, Darya Parshin, Daniil Cherevko, Alexander Akulov, Andrey Sci Rep Article Type 1 diabetes is a chronic autoimmune disease that affects tens of millions of people. Diabetes mellitus is one of the strongest factors in the development of cerebrovascular diseases. In this study we used NOD.CB17 Prkdcscid mice and the pharmacological model of type 1 diabetes mellitus of different duration to study changes in the cerebral vasculature. We used two combined approaches using magnetic resonance angiography both steady and transient CFD blood flow modeling. We identified the influence of type 1 diabetes on the architectonics and hemodynamics of the large blood vessels of the brain as the disease progresses. For the first time, we detected a statistically significant change in angioarchitectonics (the angles between the vessels of the circle of Willis, cross-sections areas of vessels) and hemodynamic (maximum blood flow rate, hydraulic resistance) in animals with diabetes duration of 2 months, that is manifested by the development of asymmetry of cerebral blood flow. The result shows the negative effect of diabetes on cerebral circulation as well as the practicability of CFD modeling. This may be of extensive interest, in pharmacological and preclinical studies. Nature Publishing Group UK 2021-02-17 /pmc/articles/PMC7889636/ /pubmed/33597584 http://dx.doi.org/10.1038/s41598-021-83484-7 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Yankova, Galina Tur, Darya Parshin, Daniil Cherevko, Alexander Akulov, Andrey Cerebral arterial architectonics and CFD simulation in mice with type 1 diabetes mellitus of different duration |
title | Cerebral arterial architectonics and CFD simulation in mice with type 1 diabetes mellitus of different duration |
title_full | Cerebral arterial architectonics and CFD simulation in mice with type 1 diabetes mellitus of different duration |
title_fullStr | Cerebral arterial architectonics and CFD simulation in mice with type 1 diabetes mellitus of different duration |
title_full_unstemmed | Cerebral arterial architectonics and CFD simulation in mice with type 1 diabetes mellitus of different duration |
title_short | Cerebral arterial architectonics and CFD simulation in mice with type 1 diabetes mellitus of different duration |
title_sort | cerebral arterial architectonics and cfd simulation in mice with type 1 diabetes mellitus of different duration |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7889636/ https://www.ncbi.nlm.nih.gov/pubmed/33597584 http://dx.doi.org/10.1038/s41598-021-83484-7 |
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