Population-specific causal disease effect sizes in functionally important regions impacted by selection

Many diseases exhibit population-specific causal effect sizes with trans-ethnic genetic correlations significantly less than 1, limiting trans-ethnic polygenic risk prediction. We develop a new method, S-LDXR, for stratifying squared trans-ethnic genetic correlation across genomic annotations, and a...

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Detalles Bibliográficos
Autores principales: Shi, Huwenbo, Gazal, Steven, Kanai, Masahiro, Koch, Evan M., Schoech, Armin P., Siewert, Katherine M., Kim, Samuel S., Luo, Yang, Amariuta, Tiffany, Huang, Hailiang, Okada, Yukinori, Raychaudhuri, Soumya, Sunyaev, Shamil R., Price, Alkes L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7889654/
https://www.ncbi.nlm.nih.gov/pubmed/33597505
http://dx.doi.org/10.1038/s41467-021-21286-1

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