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Cancer-Associated Fibroblasts Suppress Cancer Development: The Other Side of the Coin
Cancer-associated fibroblasts (CAFs) are the main stromal components of cancer, representing a group of heterogeneous cells. Many studies indicate that CAFs promote tumor development. Besides, evidence of the tumor suppression effects of CAFs keeps on merging. In the tumor microenvironment, multiple...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7890026/ https://www.ncbi.nlm.nih.gov/pubmed/33614646 http://dx.doi.org/10.3389/fcell.2021.613534 |
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author | Wang, Zhanhuai Yang, Qi Tan, Yinuo Tang, Yang Ye, Jun Yuan, Bin Yu, Wei |
author_facet | Wang, Zhanhuai Yang, Qi Tan, Yinuo Tang, Yang Ye, Jun Yuan, Bin Yu, Wei |
author_sort | Wang, Zhanhuai |
collection | PubMed |
description | Cancer-associated fibroblasts (CAFs) are the main stromal components of cancer, representing a group of heterogeneous cells. Many studies indicate that CAFs promote tumor development. Besides, evidence of the tumor suppression effects of CAFs keeps on merging. In the tumor microenvironment, multiple stimuli can activate fibroblasts. Notably, this does not necessarily mean the activated CAFs become strong tumor promoters immediately. The varying degree of CAFs activation makes quiescent CAFs, tumor-restraining CAFs, and tumor-promoting CAFs. Quiescent CAFs and tumor-restraining CAFs are more present in early-stage cancer, while comparatively, more tumor-promoting CAFs present in advanced-stage cancer. The underlying mechanism that balances tumor promotion or tumor inhibition effects of CAFs is mostly unknown. This review focus on the inhibitory effects of CAFs on cancer development. We describe the heterogeneous origin, markers, and metabolism in the CAFs population. Transgenetic mouse models that deplete CAFs or deplete CAFs activation signaling in the tumor stroma present direct evidence of CAFs protective effects against cancer. Moreover, we outline CAFs subpopulation and CAFs derived soluble factors that act as a tumor suppressor. Single-cell RNA-sequencing on CAFs population provides us new insight to classify CAFs subsets. Understanding the full picture of CAFs will help translate CAFs biology from bench to bedside and develop new strategies to improve precision cancer therapy. |
format | Online Article Text |
id | pubmed-7890026 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78900262021-02-19 Cancer-Associated Fibroblasts Suppress Cancer Development: The Other Side of the Coin Wang, Zhanhuai Yang, Qi Tan, Yinuo Tang, Yang Ye, Jun Yuan, Bin Yu, Wei Front Cell Dev Biol Cell and Developmental Biology Cancer-associated fibroblasts (CAFs) are the main stromal components of cancer, representing a group of heterogeneous cells. Many studies indicate that CAFs promote tumor development. Besides, evidence of the tumor suppression effects of CAFs keeps on merging. In the tumor microenvironment, multiple stimuli can activate fibroblasts. Notably, this does not necessarily mean the activated CAFs become strong tumor promoters immediately. The varying degree of CAFs activation makes quiescent CAFs, tumor-restraining CAFs, and tumor-promoting CAFs. Quiescent CAFs and tumor-restraining CAFs are more present in early-stage cancer, while comparatively, more tumor-promoting CAFs present in advanced-stage cancer. The underlying mechanism that balances tumor promotion or tumor inhibition effects of CAFs is mostly unknown. This review focus on the inhibitory effects of CAFs on cancer development. We describe the heterogeneous origin, markers, and metabolism in the CAFs population. Transgenetic mouse models that deplete CAFs or deplete CAFs activation signaling in the tumor stroma present direct evidence of CAFs protective effects against cancer. Moreover, we outline CAFs subpopulation and CAFs derived soluble factors that act as a tumor suppressor. Single-cell RNA-sequencing on CAFs population provides us new insight to classify CAFs subsets. Understanding the full picture of CAFs will help translate CAFs biology from bench to bedside and develop new strategies to improve precision cancer therapy. Frontiers Media S.A. 2021-02-04 /pmc/articles/PMC7890026/ /pubmed/33614646 http://dx.doi.org/10.3389/fcell.2021.613534 Text en Copyright © 2021 Wang, Yang, Tan, Tang, Ye, Yuan and Yu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Wang, Zhanhuai Yang, Qi Tan, Yinuo Tang, Yang Ye, Jun Yuan, Bin Yu, Wei Cancer-Associated Fibroblasts Suppress Cancer Development: The Other Side of the Coin |
title | Cancer-Associated Fibroblasts Suppress Cancer Development: The Other Side of the Coin |
title_full | Cancer-Associated Fibroblasts Suppress Cancer Development: The Other Side of the Coin |
title_fullStr | Cancer-Associated Fibroblasts Suppress Cancer Development: The Other Side of the Coin |
title_full_unstemmed | Cancer-Associated Fibroblasts Suppress Cancer Development: The Other Side of the Coin |
title_short | Cancer-Associated Fibroblasts Suppress Cancer Development: The Other Side of the Coin |
title_sort | cancer-associated fibroblasts suppress cancer development: the other side of the coin |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7890026/ https://www.ncbi.nlm.nih.gov/pubmed/33614646 http://dx.doi.org/10.3389/fcell.2021.613534 |
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