Cargando…

Cancer-Associated Fibroblasts Suppress Cancer Development: The Other Side of the Coin

Cancer-associated fibroblasts (CAFs) are the main stromal components of cancer, representing a group of heterogeneous cells. Many studies indicate that CAFs promote tumor development. Besides, evidence of the tumor suppression effects of CAFs keeps on merging. In the tumor microenvironment, multiple...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Zhanhuai, Yang, Qi, Tan, Yinuo, Tang, Yang, Ye, Jun, Yuan, Bin, Yu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7890026/
https://www.ncbi.nlm.nih.gov/pubmed/33614646
http://dx.doi.org/10.3389/fcell.2021.613534
_version_ 1783652428116131840
author Wang, Zhanhuai
Yang, Qi
Tan, Yinuo
Tang, Yang
Ye, Jun
Yuan, Bin
Yu, Wei
author_facet Wang, Zhanhuai
Yang, Qi
Tan, Yinuo
Tang, Yang
Ye, Jun
Yuan, Bin
Yu, Wei
author_sort Wang, Zhanhuai
collection PubMed
description Cancer-associated fibroblasts (CAFs) are the main stromal components of cancer, representing a group of heterogeneous cells. Many studies indicate that CAFs promote tumor development. Besides, evidence of the tumor suppression effects of CAFs keeps on merging. In the tumor microenvironment, multiple stimuli can activate fibroblasts. Notably, this does not necessarily mean the activated CAFs become strong tumor promoters immediately. The varying degree of CAFs activation makes quiescent CAFs, tumor-restraining CAFs, and tumor-promoting CAFs. Quiescent CAFs and tumor-restraining CAFs are more present in early-stage cancer, while comparatively, more tumor-promoting CAFs present in advanced-stage cancer. The underlying mechanism that balances tumor promotion or tumor inhibition effects of CAFs is mostly unknown. This review focus on the inhibitory effects of CAFs on cancer development. We describe the heterogeneous origin, markers, and metabolism in the CAFs population. Transgenetic mouse models that deplete CAFs or deplete CAFs activation signaling in the tumor stroma present direct evidence of CAFs protective effects against cancer. Moreover, we outline CAFs subpopulation and CAFs derived soluble factors that act as a tumor suppressor. Single-cell RNA-sequencing on CAFs population provides us new insight to classify CAFs subsets. Understanding the full picture of CAFs will help translate CAFs biology from bench to bedside and develop new strategies to improve precision cancer therapy.
format Online
Article
Text
id pubmed-7890026
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-78900262021-02-19 Cancer-Associated Fibroblasts Suppress Cancer Development: The Other Side of the Coin Wang, Zhanhuai Yang, Qi Tan, Yinuo Tang, Yang Ye, Jun Yuan, Bin Yu, Wei Front Cell Dev Biol Cell and Developmental Biology Cancer-associated fibroblasts (CAFs) are the main stromal components of cancer, representing a group of heterogeneous cells. Many studies indicate that CAFs promote tumor development. Besides, evidence of the tumor suppression effects of CAFs keeps on merging. In the tumor microenvironment, multiple stimuli can activate fibroblasts. Notably, this does not necessarily mean the activated CAFs become strong tumor promoters immediately. The varying degree of CAFs activation makes quiescent CAFs, tumor-restraining CAFs, and tumor-promoting CAFs. Quiescent CAFs and tumor-restraining CAFs are more present in early-stage cancer, while comparatively, more tumor-promoting CAFs present in advanced-stage cancer. The underlying mechanism that balances tumor promotion or tumor inhibition effects of CAFs is mostly unknown. This review focus on the inhibitory effects of CAFs on cancer development. We describe the heterogeneous origin, markers, and metabolism in the CAFs population. Transgenetic mouse models that deplete CAFs or deplete CAFs activation signaling in the tumor stroma present direct evidence of CAFs protective effects against cancer. Moreover, we outline CAFs subpopulation and CAFs derived soluble factors that act as a tumor suppressor. Single-cell RNA-sequencing on CAFs population provides us new insight to classify CAFs subsets. Understanding the full picture of CAFs will help translate CAFs biology from bench to bedside and develop new strategies to improve precision cancer therapy. Frontiers Media S.A. 2021-02-04 /pmc/articles/PMC7890026/ /pubmed/33614646 http://dx.doi.org/10.3389/fcell.2021.613534 Text en Copyright © 2021 Wang, Yang, Tan, Tang, Ye, Yuan and Yu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Wang, Zhanhuai
Yang, Qi
Tan, Yinuo
Tang, Yang
Ye, Jun
Yuan, Bin
Yu, Wei
Cancer-Associated Fibroblasts Suppress Cancer Development: The Other Side of the Coin
title Cancer-Associated Fibroblasts Suppress Cancer Development: The Other Side of the Coin
title_full Cancer-Associated Fibroblasts Suppress Cancer Development: The Other Side of the Coin
title_fullStr Cancer-Associated Fibroblasts Suppress Cancer Development: The Other Side of the Coin
title_full_unstemmed Cancer-Associated Fibroblasts Suppress Cancer Development: The Other Side of the Coin
title_short Cancer-Associated Fibroblasts Suppress Cancer Development: The Other Side of the Coin
title_sort cancer-associated fibroblasts suppress cancer development: the other side of the coin
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7890026/
https://www.ncbi.nlm.nih.gov/pubmed/33614646
http://dx.doi.org/10.3389/fcell.2021.613534
work_keys_str_mv AT wangzhanhuai cancerassociatedfibroblastssuppresscancerdevelopmenttheothersideofthecoin
AT yangqi cancerassociatedfibroblastssuppresscancerdevelopmenttheothersideofthecoin
AT tanyinuo cancerassociatedfibroblastssuppresscancerdevelopmenttheothersideofthecoin
AT tangyang cancerassociatedfibroblastssuppresscancerdevelopmenttheothersideofthecoin
AT yejun cancerassociatedfibroblastssuppresscancerdevelopmenttheothersideofthecoin
AT yuanbin cancerassociatedfibroblastssuppresscancerdevelopmenttheothersideofthecoin
AT yuwei cancerassociatedfibroblastssuppresscancerdevelopmenttheothersideofthecoin