The Roles of circRNAs in Liver Cancer Immunity

Circular RNAs (circRNAs) are stable covalently closed non-coding RNAs (ncRNAs). Many studies indicate that circRNAs are involved in the pathological and physiological processes of liver cancer. However, the functions of circRNAs in liver cancer immunity are less known. In this review, we summarized...

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Detalles Bibliográficos
Autores principales: Tang, Ying, Jiang, Mei, Jiang, Hai-Mei, Ye, Zeng Jie, Huang, Yu-Sheng, Li, Xiu-Shen, Qin, Bin-Yu, Zhou, Rui-Sheng, Pan, Hua-Feng, Zheng, Da-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7890029/
https://www.ncbi.nlm.nih.gov/pubmed/33614486
http://dx.doi.org/10.3389/fonc.2020.598464
Descripción
Sumario:Circular RNAs (circRNAs) are stable covalently closed non-coding RNAs (ncRNAs). Many studies indicate that circRNAs are involved in the pathological and physiological processes of liver cancer. However, the functions of circRNAs in liver cancer immunity are less known. In this review, we summarized the functions of circRNAs in liver cancer, including proliferative, metastasis and apoptosis, liver cancer stemness, cell cycle, immune evasion, glycolysis, angiogenesis, drug resistance/sensitizer, and senescence. Immune escape is considered to be one of the hallmarks of cancer development, and circRNA participates in the immune escape of liver cancer cells by regulating natural killer (NK) cell function. CircRNAs may provide new ideas for immunotherapy in liver cancer.

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