The Roles of circRNAs in Liver Cancer Immunity

Circular RNAs (circRNAs) are stable covalently closed non-coding RNAs (ncRNAs). Many studies indicate that circRNAs are involved in the pathological and physiological processes of liver cancer. However, the functions of circRNAs in liver cancer immunity are less known. In this review, we summarized...

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Autores principales: Tang, Ying, Jiang, Mei, Jiang, Hai-Mei, Ye, Zeng Jie, Huang, Yu-Sheng, Li, Xiu-Shen, Qin, Bin-Yu, Zhou, Rui-Sheng, Pan, Hua-Feng, Zheng, Da-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7890029/
https://www.ncbi.nlm.nih.gov/pubmed/33614486
http://dx.doi.org/10.3389/fonc.2020.598464
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author Tang, Ying
Jiang, Mei
Jiang, Hai-Mei
Ye, Zeng Jie
Huang, Yu-Sheng
Li, Xiu-Shen
Qin, Bin-Yu
Zhou, Rui-Sheng
Pan, Hua-Feng
Zheng, Da-Yong
author_facet Tang, Ying
Jiang, Mei
Jiang, Hai-Mei
Ye, Zeng Jie
Huang, Yu-Sheng
Li, Xiu-Shen
Qin, Bin-Yu
Zhou, Rui-Sheng
Pan, Hua-Feng
Zheng, Da-Yong
author_sort Tang, Ying
collection PubMed
description Circular RNAs (circRNAs) are stable covalently closed non-coding RNAs (ncRNAs). Many studies indicate that circRNAs are involved in the pathological and physiological processes of liver cancer. However, the functions of circRNAs in liver cancer immunity are less known. In this review, we summarized the functions of circRNAs in liver cancer, including proliferative, metastasis and apoptosis, liver cancer stemness, cell cycle, immune evasion, glycolysis, angiogenesis, drug resistance/sensitizer, and senescence. Immune escape is considered to be one of the hallmarks of cancer development, and circRNA participates in the immune escape of liver cancer cells by regulating natural killer (NK) cell function. CircRNAs may provide new ideas for immunotherapy in liver cancer.
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spelling pubmed-78900292021-02-19 The Roles of circRNAs in Liver Cancer Immunity Tang, Ying Jiang, Mei Jiang, Hai-Mei Ye, Zeng Jie Huang, Yu-Sheng Li, Xiu-Shen Qin, Bin-Yu Zhou, Rui-Sheng Pan, Hua-Feng Zheng, Da-Yong Front Oncol Oncology Circular RNAs (circRNAs) are stable covalently closed non-coding RNAs (ncRNAs). Many studies indicate that circRNAs are involved in the pathological and physiological processes of liver cancer. However, the functions of circRNAs in liver cancer immunity are less known. In this review, we summarized the functions of circRNAs in liver cancer, including proliferative, metastasis and apoptosis, liver cancer stemness, cell cycle, immune evasion, glycolysis, angiogenesis, drug resistance/sensitizer, and senescence. Immune escape is considered to be one of the hallmarks of cancer development, and circRNA participates in the immune escape of liver cancer cells by regulating natural killer (NK) cell function. CircRNAs may provide new ideas for immunotherapy in liver cancer. Frontiers Media S.A. 2021-02-04 /pmc/articles/PMC7890029/ /pubmed/33614486 http://dx.doi.org/10.3389/fonc.2020.598464 Text en Copyright © 2021 Tang, Jiang, Jiang, Ye, Huang, Li, Qin, Zhou, Pan and Zheng http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Tang, Ying
Jiang, Mei
Jiang, Hai-Mei
Ye, Zeng Jie
Huang, Yu-Sheng
Li, Xiu-Shen
Qin, Bin-Yu
Zhou, Rui-Sheng
Pan, Hua-Feng
Zheng, Da-Yong
The Roles of circRNAs in Liver Cancer Immunity
title The Roles of circRNAs in Liver Cancer Immunity
title_full The Roles of circRNAs in Liver Cancer Immunity
title_fullStr The Roles of circRNAs in Liver Cancer Immunity
title_full_unstemmed The Roles of circRNAs in Liver Cancer Immunity
title_short The Roles of circRNAs in Liver Cancer Immunity
title_sort roles of circrnas in liver cancer immunity
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7890029/
https://www.ncbi.nlm.nih.gov/pubmed/33614486
http://dx.doi.org/10.3389/fonc.2020.598464
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