Cargando…
Oral Administration of Flavonifractor plautii, a Bacteria Increased With Green Tea Consumption, Promotes Recovery From Acute Colitis in Mice via Suppression of IL-17
Flavonifractor plautii (FP) has been reported to participate in the metabolism of catechins in the human gut. However, there is limited information on the immune regulatory effects of this bacterium. We confirmed that the administration of green tea increases the abundance of FP in the gut microbiot...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7890079/ https://www.ncbi.nlm.nih.gov/pubmed/33614691 http://dx.doi.org/10.3389/fnut.2020.610946 |
_version_ | 1783652439721771008 |
---|---|
author | Mikami, Ayane Ogita, Tasuku Namai, Fu Shigemori, Suguru Sato, Takashi Shimosato, Takeshi |
author_facet | Mikami, Ayane Ogita, Tasuku Namai, Fu Shigemori, Suguru Sato, Takashi Shimosato, Takeshi |
author_sort | Mikami, Ayane |
collection | PubMed |
description | Flavonifractor plautii (FP) has been reported to participate in the metabolism of catechins in the human gut. However, there is limited information on the immune regulatory effects of this bacterium. We confirmed that the administration of green tea increases the abundance of FP in the gut microbiota and investigated the effect of FP in a mouse colitis model. Mice were orally administered FP for 10 consecutive days; colonic inflammation was evaluated daily on the basis of stool consistency, gross rectal bleeding, and body weight. In the dextran sodium sulfate model, FP-exposed animals exhibited lower levels of inflammation and strong inhibition of interleukin (IL)-17 signaling. Moreover, lipoteichoic acid from FP was identified as the active component mediating IL-17 suppression. Thus, oral administration of FP appears to modulate gut inflammation and represents a viable and inexpensive oral microbial therapeutic. |
format | Online Article Text |
id | pubmed-7890079 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78900792021-02-19 Oral Administration of Flavonifractor plautii, a Bacteria Increased With Green Tea Consumption, Promotes Recovery From Acute Colitis in Mice via Suppression of IL-17 Mikami, Ayane Ogita, Tasuku Namai, Fu Shigemori, Suguru Sato, Takashi Shimosato, Takeshi Front Nutr Nutrition Flavonifractor plautii (FP) has been reported to participate in the metabolism of catechins in the human gut. However, there is limited information on the immune regulatory effects of this bacterium. We confirmed that the administration of green tea increases the abundance of FP in the gut microbiota and investigated the effect of FP in a mouse colitis model. Mice were orally administered FP for 10 consecutive days; colonic inflammation was evaluated daily on the basis of stool consistency, gross rectal bleeding, and body weight. In the dextran sodium sulfate model, FP-exposed animals exhibited lower levels of inflammation and strong inhibition of interleukin (IL)-17 signaling. Moreover, lipoteichoic acid from FP was identified as the active component mediating IL-17 suppression. Thus, oral administration of FP appears to modulate gut inflammation and represents a viable and inexpensive oral microbial therapeutic. Frontiers Media S.A. 2021-02-04 /pmc/articles/PMC7890079/ /pubmed/33614691 http://dx.doi.org/10.3389/fnut.2020.610946 Text en Copyright © 2021 Mikami, Ogita, Namai, Shigemori, Sato and Shimosato. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Nutrition Mikami, Ayane Ogita, Tasuku Namai, Fu Shigemori, Suguru Sato, Takashi Shimosato, Takeshi Oral Administration of Flavonifractor plautii, a Bacteria Increased With Green Tea Consumption, Promotes Recovery From Acute Colitis in Mice via Suppression of IL-17 |
title | Oral Administration of Flavonifractor plautii, a Bacteria Increased With Green Tea Consumption, Promotes Recovery From Acute Colitis in Mice via Suppression of IL-17 |
title_full | Oral Administration of Flavonifractor plautii, a Bacteria Increased With Green Tea Consumption, Promotes Recovery From Acute Colitis in Mice via Suppression of IL-17 |
title_fullStr | Oral Administration of Flavonifractor plautii, a Bacteria Increased With Green Tea Consumption, Promotes Recovery From Acute Colitis in Mice via Suppression of IL-17 |
title_full_unstemmed | Oral Administration of Flavonifractor plautii, a Bacteria Increased With Green Tea Consumption, Promotes Recovery From Acute Colitis in Mice via Suppression of IL-17 |
title_short | Oral Administration of Flavonifractor plautii, a Bacteria Increased With Green Tea Consumption, Promotes Recovery From Acute Colitis in Mice via Suppression of IL-17 |
title_sort | oral administration of flavonifractor plautii, a bacteria increased with green tea consumption, promotes recovery from acute colitis in mice via suppression of il-17 |
topic | Nutrition |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7890079/ https://www.ncbi.nlm.nih.gov/pubmed/33614691 http://dx.doi.org/10.3389/fnut.2020.610946 |
work_keys_str_mv | AT mikamiayane oraladministrationofflavonifractorplautiiabacteriaincreasedwithgreenteaconsumptionpromotesrecoveryfromacutecolitisinmiceviasuppressionofil17 AT ogitatasuku oraladministrationofflavonifractorplautiiabacteriaincreasedwithgreenteaconsumptionpromotesrecoveryfromacutecolitisinmiceviasuppressionofil17 AT namaifu oraladministrationofflavonifractorplautiiabacteriaincreasedwithgreenteaconsumptionpromotesrecoveryfromacutecolitisinmiceviasuppressionofil17 AT shigemorisuguru oraladministrationofflavonifractorplautiiabacteriaincreasedwithgreenteaconsumptionpromotesrecoveryfromacutecolitisinmiceviasuppressionofil17 AT satotakashi oraladministrationofflavonifractorplautiiabacteriaincreasedwithgreenteaconsumptionpromotesrecoveryfromacutecolitisinmiceviasuppressionofil17 AT shimosatotakeshi oraladministrationofflavonifractorplautiiabacteriaincreasedwithgreenteaconsumptionpromotesrecoveryfromacutecolitisinmiceviasuppressionofil17 |