Coinfection with influenza A virus enhances SARS-CoV-2 infectivity

The upcoming flu season in the Northern Hemisphere merging with the current COVID-19 pandemic raises a potentially severe threat to public health. Through experimental coinfection with influenza A virus (IAV) and either pseudotyped or live SARS-CoV-2 virus, we found that IAV preinfection significant...

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Detalles Bibliográficos
Autores principales: Bai, Lei, Zhao, Yongliang, Dong, Jiazhen, Liang, Simeng, Guo, Ming, Liu, Xinjin, Wang, Xin, Huang, Zhixiang, Sun, Xiaoyi, Zhang, Zhen, Dong, Lianghui, Liu, Qianyun, Zheng, Yucheng, Niu, Danping, Xiang, Min, Song, Kun, Ye, Jiajie, Zheng, Wenchao, Tang, Zhidong, Tang, Mingliang, Zhou, Yu, Shen, Chao, Dai, Ming, Zhou, Li, Chen, Yu, Yan, Huan, Lan, Ke, Xu, Ke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7890106/
https://www.ncbi.nlm.nih.gov/pubmed/33603116
http://dx.doi.org/10.1038/s41422-021-00473-1
Descripción
Sumario:The upcoming flu season in the Northern Hemisphere merging with the current COVID-19 pandemic raises a potentially severe threat to public health. Through experimental coinfection with influenza A virus (IAV) and either pseudotyped or live SARS-CoV-2 virus, we found that IAV preinfection significantly promoted the infectivity of SARS-CoV-2 in a broad range of cell types. Remarkably, in vivo, increased SARS-CoV-2 viral load and more severe lung damage were observed in mice coinfected with IAV. Moreover, such enhancement of SARS-CoV-2 infectivity was not observed with several other respiratory viruses, likely due to a unique feature of IAV to elevate ACE2 expression. This study illustrates that IAV has a unique ability to aggravate SARS-CoV-2 infection, and thus, prevention of IAV infection is of great significance during the COVID-19 pandemic.

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