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Neuromuscular and vascular hamartoma of the small intestine in an F344 rat

An intestinal mass was found in the border area of the jejunum and ileum of a 110-week-old male F344 rat. Histopathologically, the mass protruded into the lumen and was covered with intestinal epithelium, exhibiting a normal architecture. The lesion was located in the submucosa and consisted of loos...

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Autores principales: Yamada, Takanori, Toyoda, Takeshi, Ide, Tetsuya, Matsushita, Kohei, Morikawa, Tomomi, Ogawa, Kumiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society of Toxicologic Pathology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7890160/
https://www.ncbi.nlm.nih.gov/pubmed/33627952
http://dx.doi.org/10.1293/tox.2020-0059
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author Yamada, Takanori
Toyoda, Takeshi
Ide, Tetsuya
Matsushita, Kohei
Morikawa, Tomomi
Ogawa, Kumiko
author_facet Yamada, Takanori
Toyoda, Takeshi
Ide, Tetsuya
Matsushita, Kohei
Morikawa, Tomomi
Ogawa, Kumiko
author_sort Yamada, Takanori
collection PubMed
description An intestinal mass was found in the border area of the jejunum and ileum of a 110-week-old male F344 rat. Histopathologically, the mass protruded into the lumen and was covered with intestinal epithelium, exhibiting a normal architecture. The lesion was located in the submucosa and consisted of loose connective tissue, smooth muscle, scattered ganglion cells, and blood vessels of various sizes. Although these components showed an irregular and disordered structure, no cellular atypia, increased proliferation activity, or invasive growth to adjacent tissues were detected. Immunohistochemical analyses revealed that smooth muscle, ganglion, and endothelial cells were positive for α-smooth muscle actin and vimentin, S-100, and CD34 and von Willebrand factor, respectively, indicating maturation of these cells. Thus, the mass was diagnosed as a neuromuscular and vascular hamartoma of the small intestine. To the best of our knowledge, this is the first report of this type of lesion in rodents.
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spelling pubmed-78901602021-02-23 Neuromuscular and vascular hamartoma of the small intestine in an F344 rat Yamada, Takanori Toyoda, Takeshi Ide, Tetsuya Matsushita, Kohei Morikawa, Tomomi Ogawa, Kumiko J Toxicol Pathol Case Report An intestinal mass was found in the border area of the jejunum and ileum of a 110-week-old male F344 rat. Histopathologically, the mass protruded into the lumen and was covered with intestinal epithelium, exhibiting a normal architecture. The lesion was located in the submucosa and consisted of loose connective tissue, smooth muscle, scattered ganglion cells, and blood vessels of various sizes. Although these components showed an irregular and disordered structure, no cellular atypia, increased proliferation activity, or invasive growth to adjacent tissues were detected. Immunohistochemical analyses revealed that smooth muscle, ganglion, and endothelial cells were positive for α-smooth muscle actin and vimentin, S-100, and CD34 and von Willebrand factor, respectively, indicating maturation of these cells. Thus, the mass was diagnosed as a neuromuscular and vascular hamartoma of the small intestine. To the best of our knowledge, this is the first report of this type of lesion in rodents. Japanese Society of Toxicologic Pathology 2020-11-17 2021-01 /pmc/articles/PMC7890160/ /pubmed/33627952 http://dx.doi.org/10.1293/tox.2020-0059 Text en ©2021 The Japanese Society of Toxicologic Pathology This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Yamada, Takanori
Toyoda, Takeshi
Ide, Tetsuya
Matsushita, Kohei
Morikawa, Tomomi
Ogawa, Kumiko
Neuromuscular and vascular hamartoma of the small intestine in an F344 rat
title Neuromuscular and vascular hamartoma of the small intestine in an F344 rat
title_full Neuromuscular and vascular hamartoma of the small intestine in an F344 rat
title_fullStr Neuromuscular and vascular hamartoma of the small intestine in an F344 rat
title_full_unstemmed Neuromuscular and vascular hamartoma of the small intestine in an F344 rat
title_short Neuromuscular and vascular hamartoma of the small intestine in an F344 rat
title_sort neuromuscular and vascular hamartoma of the small intestine in an f344 rat
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7890160/
https://www.ncbi.nlm.nih.gov/pubmed/33627952
http://dx.doi.org/10.1293/tox.2020-0059
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