Cargando…

Adiponectin forms a complex with atherogenic LDL and inhibits its downstream effects

Adiponectin, an adipocyte-derived protein, has antiatherogenic and antidiabetic effects, but how it confers the atherogenic effects is not well known. To study the antiatherogenic mechanisms of adiponectin, we examined whether it interacts with atherogenic low density lipoprotein (LDL) to attenuate...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kakino, Akemi, Fujita, Yoshiko, Ke, Liang-Yin, Chan, Hua-Chen, Tsai, Ming-Hsien, Dai, Chia-Yen, Chen, Chu-Huang, Sawamura, Tatsuya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7890179/ https://www.ncbi.nlm.nih.gov/pubmed/33410750 http://dx.doi.org/10.1194/jlr.RA120000767

Ejemplares similares

LOX-1 in Ischemic Stroke
por: Sawamura, Tatsuya, et al.
Publicado: (2017)

Autoimmune Rheumatic Diseases: An Update on the Role of Atherogenic Electronegative LDL and Potential Therapeutic Strategies
por: Chen, Der-Yuan, et al.
Publicado: (2021)

The Discovery of LOX-1, its Ligands and Clinical Significance
por: Yoshimoto, Ryo, et al.
Publicado: (2011)

Critical role of oxidized LDL receptor-1 in intravascular thrombosis in a severe influenza mouse model
por: Ohno, Marumi, et al.
Publicado: (2021)

A Novel Cell-Free, Non-Fluorescent Method to Measure LOX-1-Binding Activity Corresponding to The Functional Activity of HDL
por: Kakino, Akemi, et al.
Publicado: (2019)

Atherogenic L5 LDL induces cardiomyocyte apoptosis and inhibits K(ATP) channels through CaMKII activation
por: Ma, Yanzhuo, et al.
Publicado: (2020)

Erratum to “Procyanidins are potent inhibitors of LOX-1: a new player in the French Paradox”: [Proc. Jpn. Acad., Ser. B 87, No. 3, 104–113]
por: NISHIZUKA, Taichi, et al.
Publicado: (2011)

Procyanidins are potent inhibitors of LOX-1: a new player in the French Paradox
por: NISHIZUKA, Taichi, et al.
Publicado: (2011)

High Levels of Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in Acute Stroke: An Age- and Sex-Matched Cross-Sectional Study
por: Yokota, Chiaki, et al.
Publicado: (2016)

Deletion of LOX-1 Protects against Heart Failure Induced by Doxorubicin
por: Yokoyama, Chiharu, et al.
Publicado: (2016)

Prevalence of LDL atherogenic phenotype in patients with systemic lupus erythematosus
por: Olusi, Samuel O, et al.
Publicado: (2011)

Atherosclerosis Development and Progression: The Role of Atherogenic Small, Dense LDL
por: Vekic, Jelena, et al.
Publicado: (2022)

Electronegative LDL from Rabbits Fed with Atherogenic Diet Is Highly Proinflammatory
por: Chang, Po-Yuan, et al.
Publicado: (2019)

Human electronegative LDL induces mitochondrial dysfunction and premature senescence of vascular cells in vivo
por: Wang, Yu‐Chen, et al.
Publicado: (2018)

Role of HDL function and LDL atherogenicity on cardiovascular risk: A comprehensive examination
por: Hernáez, Álvaro, et al.
Publicado: (2019)

The endocytosis of oxidized LDL via the activation of the angiotensin II type 1 receptor
por: Takahashi, Toshimasa, et al.
Publicado: (2021)

In Vitro Interactions of Extracellular Histones with LDL Suggest a Potential Pro-Atherogenic Role
por: Pemberton, Alan D., et al.
Publicado: (2010)

Detection of a High Ratio of Soluble to Membrane‐Bound LOX‐1 in Aspirated Coronary Thrombi From Patients With ST‐Segment–Elevation Myocardial Infarction
por: Lee, An‐Sheng, et al.
Publicado: (2020)

Insulin Resistance Is Associated With Impaired HDL Function and Atherogenic Modification of LDL in Polycystic Ovarian Syndrome
por: Ho, Jan Hoong, et al.
Publicado: (2021)

Tissue-specific role and associated downstream signaling pathways of adiponectin
por: Roy, Bipradas, et al.
Publicado: (2021)

Lipoproteins and Cardiovascular Disease: An Update on the Clinical Significance of Atherogenic Small, Dense LDL and New Therapeutical Options
por: Rizvi, Ali A., et al.
Publicado: (2021)

Novel Pharmaceutical and Nutraceutical-Based Approaches for Cardiovascular Diseases Prevention Targeting Atherogenic Small Dense LDL
por: Vekic, Jelena, et al.
Publicado: (2022)

Cholesterol-induced mammary tumorigenesis is enhanced by adiponectin deficiency: role of LDL receptor upregulation
por: Liu, Jing, et al.
Publicado: (2013)

Protective roles of adiponectin and molecular signatures of HNF4α and PPARα as downstream targets of adiponectin in pancreatic β cells
por: Onodera, Toshiharu, et al.
Publicado: (2023)

Glycation of LDL by Methylglyoxal Increases Arterial Atherogenicity: A Possible Contributor to Increased Risk of Cardiovascular Disease in Diabetes
por: Rabbani, Naila, et al.
Publicado: (2011)

A promoter variant of the APOA5 gene increases atherogenic LDL levels and arterial stiffness in hypertriglyceridemic patients
por: Kim, Minjoo, et al.
Publicado: (2017)

Gender disparity in LDL-induced cardiovascular damage and the protective role of estrogens against electronegative LDL
por: Lee, An-Sheng, et al.
Publicado: (2014)

Effect of Ezetimibe on LDL-C Lowering and Atherogenic Lipoprotein Profiles in Type 2 Diabetic Patients Poorly Controlled by Statins
por: Sakamoto, Kentaro, et al.
Publicado: (2015)

Discordantly normal ApoB relative to elevated LDL-C in persons with metabolic disorders: A marker of atherogenic heterogeneity
por: Razavi, Alexander C., et al.
Publicado: (2021)

Implication of Low HDL-c Levels in Patients with Average LDL-c Levels: A Focus on Oxidized LDL, Large HDL Subpopulation, and Adiponectin
por: Mascarenhas-Melo, Filipa, et al.
Publicado: (2013)

Inhibition of LDL oxidation and oxidized LDL-induced foam cell formation in RAW 264.7 cells show anti-atherogenic properties of a foliar methanol extract of Scoparia dulcis
por: Nambiar, Sinjitha S., et al.
Publicado: (2014)

Effects of a very high saturated fat diet on LDL particles in adults with atherogenic dyslipidemia: A randomized controlled trial
por: Chiu, Sally, et al.
Publicado: (2017)

Electronegative LDL-mediated cardiac electrical remodeling in a rat model of chronic kidney disease
por: Lee, An-Sheng, et al.
Publicado: (2017)

Mendelian randomization study reveals a causal relationship between adiponectin and LDL cholesterol in Africans
por: Meeks, Karlijn A. C., et al.
Publicado: (2022)

Cultivation and Immortalization of Human B-Cells Producing a Human Monoclonal IgM Antibody Binding to MDA-LDL: Further Evidence for Formation of Atherogenic MDA-LDL Adducts in Humans In Vivo
por: Tatzber, Franz, et al.
Publicado: (2017)

Pro‐atherogenic actions of signal transducer and activator of transcription 1 serine 727 phosphorylation in LDL receptor deficient mice via modulation of plaque inflammation
por: Al‐Ahmadi, Wijdan, et al.
Publicado: (2021)

Atherogenic dyslipidemia
por: Manjunath, C. N., et al.
Publicado: (2013)

Increased Small Dense LDL and Decreased Paraoxonase Enzyme Activity Reveals Formation of an Atherogenic Risk in Streptozotocin-Induced Diabetic Guinea Pigs
por: Aslan, Mutay, et al.
Publicado: (2013)

Abnormal Blood Coagulation and Kidney Damage in Aged Hamsters Infected with Severe Acute Respiratory Syndrome Coronavirus 2
por: Ohno, Marumi, et al.
Publicado: (2021)

Statins but not fibrates improve the atherogenic to anti-atherogenic lipoprotein particle ratio: a randomized crossover study
por: Chan, Sammy Y, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_ajq0lcj1q65efm46oqf8tu2pra