Orexin-A/Hypocretin-1 Controls the VTA-NAc Mesolimbic Pathway via Endocannabinoid-Mediated Disinhibition of Dopaminergic Neurons in Obese Mice

Disinhibition of orexin-A/hypocretin-1 (OX-A) release occurs to several output areas of the lateral hypothalamus (LH) in the brain of leptin knockout obese ob/ob mice. In this study, we have investigated whether a similar increase of OX-A release occurs to the ventral tegmental area (VTA), an orexin...

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Detalles Bibliográficos
Autores principales: Tunisi, Lea, D'Angelo, Livia, Fernández-Rilo, Alba Clara, Forte, Nicola, Piscitelli, Fabiana, Imperatore, Roberta, de Girolamo, Paolo, Di Marzo, Vincenzo, Cristino, Luigia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7890184/
https://www.ncbi.nlm.nih.gov/pubmed/33613258
http://dx.doi.org/10.3389/fnsyn.2021.622405

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