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A Single Case Feasibility Study of Sensorimotor Rhythm Neurofeedback in Parkinson’s Disease

Electroencephalographic activity over the sensorimotor cortex has been one of the best studied targets for neurofeedback therapy. Parkinson’s disease patients display abnormal brain rhythms in the motor cortex caused by increased synchrony in the basal ganglia-cortical pathway. Few studies have exam...

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Autores principales: Cook, Alexander J., Pfeifer, Kristina J., Tass, Peter A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7890190/
https://www.ncbi.nlm.nih.gov/pubmed/33613185
http://dx.doi.org/10.3389/fnins.2021.623317
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author Cook, Alexander J.
Pfeifer, Kristina J.
Tass, Peter A.
author_facet Cook, Alexander J.
Pfeifer, Kristina J.
Tass, Peter A.
author_sort Cook, Alexander J.
collection PubMed
description Electroencephalographic activity over the sensorimotor cortex has been one of the best studied targets for neurofeedback therapy. Parkinson’s disease patients display abnormal brain rhythms in the motor cortex caused by increased synchrony in the basal ganglia-cortical pathway. Few studies have examined the effects of sensorimotor-based neurofeedback therapy in humans with PD. In this pilot study, one patient, diagnosed with Parkinson’s disease 10 years prior, participated in two consecutive days of EEG neurofeedback training to increase sensorimotor rhythm (SMR) power over the motor cortex. Using a visual display connected to ongoing EEG, the patient voluntarily manipulated SMR power, and he/she was awarded with points to positively reinforce successful increases over a predefined threshold. Recorded EEG data were source localized and analyzed for the occurrence of high amplitude bursts of SMR activity as well as bursts in the beta frequency band in the precentral cortex. The rate of SMR bursts increased with each subsequent training session, while the rate of beta bursts only increased on the final session. Relative power in the beta band, a marker of PD symptom severity, decreased over the motor cortex in the later session. These results provide first evidence for the feasibility of SMR neurofeedback training as a non-invasive therapy for reducing Parkinson’s disease related activity and upregulating SMR in the human motor cortex.
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spelling pubmed-78901902021-02-19 A Single Case Feasibility Study of Sensorimotor Rhythm Neurofeedback in Parkinson’s Disease Cook, Alexander J. Pfeifer, Kristina J. Tass, Peter A. Front Neurosci Neuroscience Electroencephalographic activity over the sensorimotor cortex has been one of the best studied targets for neurofeedback therapy. Parkinson’s disease patients display abnormal brain rhythms in the motor cortex caused by increased synchrony in the basal ganglia-cortical pathway. Few studies have examined the effects of sensorimotor-based neurofeedback therapy in humans with PD. In this pilot study, one patient, diagnosed with Parkinson’s disease 10 years prior, participated in two consecutive days of EEG neurofeedback training to increase sensorimotor rhythm (SMR) power over the motor cortex. Using a visual display connected to ongoing EEG, the patient voluntarily manipulated SMR power, and he/she was awarded with points to positively reinforce successful increases over a predefined threshold. Recorded EEG data were source localized and analyzed for the occurrence of high amplitude bursts of SMR activity as well as bursts in the beta frequency band in the precentral cortex. The rate of SMR bursts increased with each subsequent training session, while the rate of beta bursts only increased on the final session. Relative power in the beta band, a marker of PD symptom severity, decreased over the motor cortex in the later session. These results provide first evidence for the feasibility of SMR neurofeedback training as a non-invasive therapy for reducing Parkinson’s disease related activity and upregulating SMR in the human motor cortex. Frontiers Media S.A. 2021-02-04 /pmc/articles/PMC7890190/ /pubmed/33613185 http://dx.doi.org/10.3389/fnins.2021.623317 Text en Copyright © 2021 Cook, Pfeifer and Tass. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Cook, Alexander J.
Pfeifer, Kristina J.
Tass, Peter A.
A Single Case Feasibility Study of Sensorimotor Rhythm Neurofeedback in Parkinson’s Disease
title A Single Case Feasibility Study of Sensorimotor Rhythm Neurofeedback in Parkinson’s Disease
title_full A Single Case Feasibility Study of Sensorimotor Rhythm Neurofeedback in Parkinson’s Disease
title_fullStr A Single Case Feasibility Study of Sensorimotor Rhythm Neurofeedback in Parkinson’s Disease
title_full_unstemmed A Single Case Feasibility Study of Sensorimotor Rhythm Neurofeedback in Parkinson’s Disease
title_short A Single Case Feasibility Study of Sensorimotor Rhythm Neurofeedback in Parkinson’s Disease
title_sort single case feasibility study of sensorimotor rhythm neurofeedback in parkinson’s disease
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7890190/
https://www.ncbi.nlm.nih.gov/pubmed/33613185
http://dx.doi.org/10.3389/fnins.2021.623317
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