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Insights into the kinetics and dynamics of the furin-cleaved form of PCSK9

Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates cholesterol metabolism by inducing the degradation of hepatic low density lipoprotein receptors (LDLRs). Plasma PCSK9 has 2 main molecular forms: a 62 kDa mature form (PCSK9_62) and a 55 kDa, furin-cleaved form (PCSK9_55). PCSK9_55 is c...

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Detalles Bibliográficos
Autores principales:	Oleaga, Carlota, Hay, Joshua, Gurcan, Emma, David, Larry L., Mueller, Paul A., Tavori, Hagai, Shapiro, Michael D., Pamir, Nathalie, Fazio, Sergio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7890205/ https://www.ncbi.nlm.nih.gov/pubmed/33429337 http://dx.doi.org/10.1194/jlr.RA120000964

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