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Long non-coding RNA SNHG25 promotes epithelial ovarian cancer progression by up-regulating COMP

Long non-coding RNAs (lncRNAs) play a pivotal role in the genesis and development of cancer. The role and molecular mechanisms of SNHG25 in epithelial ovarian cancer (EOC) have not been investigated. In the present study, we showed that SNHG25 expression was up-regulated in EOC tissues relative to n...

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Autores principales: Liu, Yinglei, Xu, Boqun, Liu, Manhua, Qiao, Haifeng, Zhang, Siming, Qiu, Junjun, Ying, Xiaoyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7890321/
https://www.ncbi.nlm.nih.gov/pubmed/33613753
http://dx.doi.org/10.7150/jca.47344
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author Liu, Yinglei
Xu, Boqun
Liu, Manhua
Qiao, Haifeng
Zhang, Siming
Qiu, Junjun
Ying, Xiaoyan
author_facet Liu, Yinglei
Xu, Boqun
Liu, Manhua
Qiao, Haifeng
Zhang, Siming
Qiu, Junjun
Ying, Xiaoyan
author_sort Liu, Yinglei
collection PubMed
description Long non-coding RNAs (lncRNAs) play a pivotal role in the genesis and development of cancer. The role and molecular mechanisms of SNHG25 in epithelial ovarian cancer (EOC) have not been investigated. In the present study, we showed that SNHG25 expression was up-regulated in EOC tissues relative to normal ovarian tissues. In vitro, functional experiments demonstrated that high expression of SNHG25 promoted proliferation, migration and invasion, and decreased apoptosis, in ovarian cancer cell lines. In vivo, downregulation of SNHG25 inhibited the growth (tumor volume) of subcutaneous xenografts in nude mice. High-throughput sequencing and western blot analysis showed a significant decrease in the expression of COMP mRNA and protein in SNHG25 knockdown compared to control ovarian cancer cells. These data suggest that SNHG25 promotes EOC progression by regulating COMP, serving as a potential biomarker for EOC.
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spelling pubmed-78903212021-02-18 Long non-coding RNA SNHG25 promotes epithelial ovarian cancer progression by up-regulating COMP Liu, Yinglei Xu, Boqun Liu, Manhua Qiao, Haifeng Zhang, Siming Qiu, Junjun Ying, Xiaoyan J Cancer Research Paper Long non-coding RNAs (lncRNAs) play a pivotal role in the genesis and development of cancer. The role and molecular mechanisms of SNHG25 in epithelial ovarian cancer (EOC) have not been investigated. In the present study, we showed that SNHG25 expression was up-regulated in EOC tissues relative to normal ovarian tissues. In vitro, functional experiments demonstrated that high expression of SNHG25 promoted proliferation, migration and invasion, and decreased apoptosis, in ovarian cancer cell lines. In vivo, downregulation of SNHG25 inhibited the growth (tumor volume) of subcutaneous xenografts in nude mice. High-throughput sequencing and western blot analysis showed a significant decrease in the expression of COMP mRNA and protein in SNHG25 knockdown compared to control ovarian cancer cells. These data suggest that SNHG25 promotes EOC progression by regulating COMP, serving as a potential biomarker for EOC. Ivyspring International Publisher 2021-01-16 /pmc/articles/PMC7890321/ /pubmed/33613753 http://dx.doi.org/10.7150/jca.47344 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Liu, Yinglei
Xu, Boqun
Liu, Manhua
Qiao, Haifeng
Zhang, Siming
Qiu, Junjun
Ying, Xiaoyan
Long non-coding RNA SNHG25 promotes epithelial ovarian cancer progression by up-regulating COMP
title Long non-coding RNA SNHG25 promotes epithelial ovarian cancer progression by up-regulating COMP
title_full Long non-coding RNA SNHG25 promotes epithelial ovarian cancer progression by up-regulating COMP
title_fullStr Long non-coding RNA SNHG25 promotes epithelial ovarian cancer progression by up-regulating COMP
title_full_unstemmed Long non-coding RNA SNHG25 promotes epithelial ovarian cancer progression by up-regulating COMP
title_short Long non-coding RNA SNHG25 promotes epithelial ovarian cancer progression by up-regulating COMP
title_sort long non-coding rna snhg25 promotes epithelial ovarian cancer progression by up-regulating comp
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7890321/
https://www.ncbi.nlm.nih.gov/pubmed/33613753
http://dx.doi.org/10.7150/jca.47344
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