circ_SMAD2 regulate colorectal cancer cells proliferation through targeting miR-1258/RPN2 signaling pathway

Circular RNAs (circRNAs) are associated with various diseases, including cancers. However, their roles in colorectal cancer (CRC) have not been established. Hsa_circ_0000847 (circ_SMAD2) is a novel circRNA that was found to be elevated in CRC cell lines and tissues. High circ_SMAD2 levels were posit...

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Detalles Bibliográficos
Autores principales: Zhang, Wei, Wu, Gang, Sun, Peichun, Zhu, Yuanzeng, Zhang, Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7890329/
https://www.ncbi.nlm.nih.gov/pubmed/33613755
http://dx.doi.org/10.7150/jca.50888
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author Zhang, Wei
Wu, Gang
Sun, Peichun
Zhu, Yuanzeng
Zhang, Han
author_facet Zhang, Wei
Wu, Gang
Sun, Peichun
Zhu, Yuanzeng
Zhang, Han
author_sort Zhang, Wei
collection PubMed
description Circular RNAs (circRNAs) are associated with various diseases, including cancers. However, their roles in colorectal cancer (CRC) have not been established. Hsa_circ_0000847 (circ_SMAD2) is a novel circRNA that was found to be elevated in CRC cell lines and tissues. High circ_SMAD2 levels were positively correlated with CRC clinicopathological features. Functional assays revealed that circ_SMAD2 enhanced CRC cell invasion, proliferation, and tumor growth. Mechanistically, circ_SMAD2 elevated Ribophorin II (RPN2) levels by inhibiting miR-1258. Therefore, circ_SMAD2 is a potential indicator for CRC progression.
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spelling pubmed-78903292021-02-18 circ_SMAD2 regulate colorectal cancer cells proliferation through targeting miR-1258/RPN2 signaling pathway Zhang, Wei Wu, Gang Sun, Peichun Zhu, Yuanzeng Zhang, Han J Cancer Research Paper Circular RNAs (circRNAs) are associated with various diseases, including cancers. However, their roles in colorectal cancer (CRC) have not been established. Hsa_circ_0000847 (circ_SMAD2) is a novel circRNA that was found to be elevated in CRC cell lines and tissues. High circ_SMAD2 levels were positively correlated with CRC clinicopathological features. Functional assays revealed that circ_SMAD2 enhanced CRC cell invasion, proliferation, and tumor growth. Mechanistically, circ_SMAD2 elevated Ribophorin II (RPN2) levels by inhibiting miR-1258. Therefore, circ_SMAD2 is a potential indicator for CRC progression. Ivyspring International Publisher 2021-01-16 /pmc/articles/PMC7890329/ /pubmed/33613755 http://dx.doi.org/10.7150/jca.50888 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Zhang, Wei
Wu, Gang
Sun, Peichun
Zhu, Yuanzeng
Zhang, Han
circ_SMAD2 regulate colorectal cancer cells proliferation through targeting miR-1258/RPN2 signaling pathway
title circ_SMAD2 regulate colorectal cancer cells proliferation through targeting miR-1258/RPN2 signaling pathway
title_full circ_SMAD2 regulate colorectal cancer cells proliferation through targeting miR-1258/RPN2 signaling pathway
title_fullStr circ_SMAD2 regulate colorectal cancer cells proliferation through targeting miR-1258/RPN2 signaling pathway
title_full_unstemmed circ_SMAD2 regulate colorectal cancer cells proliferation through targeting miR-1258/RPN2 signaling pathway
title_short circ_SMAD2 regulate colorectal cancer cells proliferation through targeting miR-1258/RPN2 signaling pathway
title_sort circ_smad2 regulate colorectal cancer cells proliferation through targeting mir-1258/rpn2 signaling pathway
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7890329/
https://www.ncbi.nlm.nih.gov/pubmed/33613755
http://dx.doi.org/10.7150/jca.50888
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