Ad- and AAV8-mediated ABCA1 gene therapy in a murine model with retinal ischemia/reperfusion injuries

The anti-inflammatory molecule annexin A1 (ANXA1) determines the ultimate fate of retinal ganglion cell (RGC) in glaucoma. Cytoplasmic and extracellular ANXA1 facilitate resolution of inflammation. However, the nuclear translocation of ANXA1 induces RGC apoptosis in a murine glaucoma model, and the...

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Detalles Bibliográficos
Autores principales: Luo, Jing, Wang, Shengli, Zhou, Zhenlong, Zhao, Yin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7890372/
https://www.ncbi.nlm.nih.gov/pubmed/33665225
http://dx.doi.org/10.1016/j.omtm.2021.01.012

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