P53-independent partial restoration of the p53 pathway in tumors with mutated p53 through ATF4 transcriptional modulation by ERK1/2 and CDK9

A long-term goal in the cancer-field has been to develop strategies for treating p53-mutated tumors. A novel small-molecule, PG3-Oc, restores p53 pathway-signaling in tumor cells with mutant-p53, independently of p53/p73. PG3-Oc partially upregulates the p53-transcriptome (13.7% of public p53 target...

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Detalles Bibliográficos
Autores principales: Tian, Xiaobing, Ahsan, Nagib, Lulla, Amriti, Lev, Avital, Abbosh, Philip, Dicker, David T., Zhang, Shengliang, El-Deiry, Wafik S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7890376/
https://www.ncbi.nlm.nih.gov/pubmed/33582407
http://dx.doi.org/10.1016/j.neo.2021.01.004

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