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Ion release from hydroxyapatite and substituted hydroxyapatites in different immersion liquids: in vitro experiments and theoretical modelling study
Multi-substituted hydroxyapatites (ms-HAPs) are currently gaining more consideration owing to their multifunctional properties and biomimetic structure, owning thus an enhanced biological potential in orthopaedic and dental applications. In this study, nano-hydroxyapatite (HAP) substituted with mult...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7890514/ https://www.ncbi.nlm.nih.gov/pubmed/33614097 http://dx.doi.org/10.1098/rsos.201785 |
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author | Mocanu, Aurora Cadar, Oana Frangopol, Petre T. Petean, Ioan Tomoaia, Gheorghe Paltinean, Gertrud-Alexandra Racz, Csaba Pal Horovitz, Ossi Tomoaia-Cotisel, Maria |
author_facet | Mocanu, Aurora Cadar, Oana Frangopol, Petre T. Petean, Ioan Tomoaia, Gheorghe Paltinean, Gertrud-Alexandra Racz, Csaba Pal Horovitz, Ossi Tomoaia-Cotisel, Maria |
author_sort | Mocanu, Aurora |
collection | PubMed |
description | Multi-substituted hydroxyapatites (ms-HAPs) are currently gaining more consideration owing to their multifunctional properties and biomimetic structure, owning thus an enhanced biological potential in orthopaedic and dental applications. In this study, nano-hydroxyapatite (HAP) substituted with multiple cations (Sr(2+), Mg(2+) and Zn(2+)) for Ca(2+) and anion ([Formula: see text]) for [Formula: see text] and OH(−), specifically HAPc-5%Sr and HAPc-10%Sr (where HAPc is HAP-1.5%Mg–0.2%Zn–0.2%Si), both lyophilized non-calcined and lyophilized calcined, were evaluated for their in vitro ions release. These nanomaterials were characterized by scanning electron microscopy, field emission-scanning electron microscopy and energy-dispersive X-ray, as well as by atomic force microscope images and by surface specific areas and porosity. Further, the release of cations and of phosphate anions were assessed from nano-HAP and ms-HAPs, both in water and in simulated body fluid, in static and simulated dynamic conditions, using inductively coupled plasma optical emission spectrometry. The release profiles were analysed and the influence of experimental conditions was determined for each of the six nanomaterials and for various periods of time. The pH of the samples soaked in the immersion liquids was also measured. The ion release mechanism was theoretically investigated using the Korsmeyer–Peppas model. The results indicated a mechanism principally based on diffusion and dissolution, with possible contribution of ion exchange. The surface of ms-HAP nanoparticles is more susceptible to dissolution into immersion liquids owing to the lattice strain provoked by simultaneous multi-substitution in HAP structure. According to the findings, it is rational to suggest that both materials HAPc-5%Sr and HAPc-10%Sr are bioactive and can be potential candidates in bone tissue regeneration. |
format | Online Article Text |
id | pubmed-7890514 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Royal Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-78905142021-02-18 Ion release from hydroxyapatite and substituted hydroxyapatites in different immersion liquids: in vitro experiments and theoretical modelling study Mocanu, Aurora Cadar, Oana Frangopol, Petre T. Petean, Ioan Tomoaia, Gheorghe Paltinean, Gertrud-Alexandra Racz, Csaba Pal Horovitz, Ossi Tomoaia-Cotisel, Maria R Soc Open Sci Chemistry Multi-substituted hydroxyapatites (ms-HAPs) are currently gaining more consideration owing to their multifunctional properties and biomimetic structure, owning thus an enhanced biological potential in orthopaedic and dental applications. In this study, nano-hydroxyapatite (HAP) substituted with multiple cations (Sr(2+), Mg(2+) and Zn(2+)) for Ca(2+) and anion ([Formula: see text]) for [Formula: see text] and OH(−), specifically HAPc-5%Sr and HAPc-10%Sr (where HAPc is HAP-1.5%Mg–0.2%Zn–0.2%Si), both lyophilized non-calcined and lyophilized calcined, were evaluated for their in vitro ions release. These nanomaterials were characterized by scanning electron microscopy, field emission-scanning electron microscopy and energy-dispersive X-ray, as well as by atomic force microscope images and by surface specific areas and porosity. Further, the release of cations and of phosphate anions were assessed from nano-HAP and ms-HAPs, both in water and in simulated body fluid, in static and simulated dynamic conditions, using inductively coupled plasma optical emission spectrometry. The release profiles were analysed and the influence of experimental conditions was determined for each of the six nanomaterials and for various periods of time. The pH of the samples soaked in the immersion liquids was also measured. The ion release mechanism was theoretically investigated using the Korsmeyer–Peppas model. The results indicated a mechanism principally based on diffusion and dissolution, with possible contribution of ion exchange. The surface of ms-HAP nanoparticles is more susceptible to dissolution into immersion liquids owing to the lattice strain provoked by simultaneous multi-substitution in HAP structure. According to the findings, it is rational to suggest that both materials HAPc-5%Sr and HAPc-10%Sr are bioactive and can be potential candidates in bone tissue regeneration. The Royal Society 2021-01-13 /pmc/articles/PMC7890514/ /pubmed/33614097 http://dx.doi.org/10.1098/rsos.201785 Text en © 2021 The Authors. http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/http://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. |
spellingShingle | Chemistry Mocanu, Aurora Cadar, Oana Frangopol, Petre T. Petean, Ioan Tomoaia, Gheorghe Paltinean, Gertrud-Alexandra Racz, Csaba Pal Horovitz, Ossi Tomoaia-Cotisel, Maria Ion release from hydroxyapatite and substituted hydroxyapatites in different immersion liquids: in vitro experiments and theoretical modelling study |
title | Ion release from hydroxyapatite and substituted hydroxyapatites in different immersion liquids: in vitro experiments and theoretical modelling study |
title_full | Ion release from hydroxyapatite and substituted hydroxyapatites in different immersion liquids: in vitro experiments and theoretical modelling study |
title_fullStr | Ion release from hydroxyapatite and substituted hydroxyapatites in different immersion liquids: in vitro experiments and theoretical modelling study |
title_full_unstemmed | Ion release from hydroxyapatite and substituted hydroxyapatites in different immersion liquids: in vitro experiments and theoretical modelling study |
title_short | Ion release from hydroxyapatite and substituted hydroxyapatites in different immersion liquids: in vitro experiments and theoretical modelling study |
title_sort | ion release from hydroxyapatite and substituted hydroxyapatites in different immersion liquids: in vitro experiments and theoretical modelling study |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7890514/ https://www.ncbi.nlm.nih.gov/pubmed/33614097 http://dx.doi.org/10.1098/rsos.201785 |
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