Efficacy of metformin and fermentable fiber combination therapy in adolescents with severe obesity and insulin resistance: study protocol for a double-blind randomized controlled trial

BACKGROUND: Accumulating evidence suggests that the metabolic effects of metformin and fermentable fibers are mediated, in part, through diverging or overlapping effects on the composition and metabolic functions of the gut microbiome. Pre-clinical animal models have established that the addition of...

Descripción completa

Detalles Bibliográficos
Autores principales: Deehan, Edward C., Colin-Ramirez, Eloisa, Triador, Lucila, Madsen, Karen L., Prado, Carla M., Field, Catherine J., Ball, Geoff D. C., Tan, Qiming, Orsso, Camila, Dinu, Irina, Pakseresht, Mohammadreza, Rubin, Daniela, Sharma, Arya M., Tun, Hein, Walter, Jens, Newgard, Christopher B., Freemark, Michael, Wine, Eytan, Haqq, Andrea M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7890810/
https://www.ncbi.nlm.nih.gov/pubmed/33596993
http://dx.doi.org/10.1186/s13063-021-05060-8

Ejemplares similares

Ejemplares similares