Does high dose intravenous acetaminophen affect liver function for PDA closure in premature neonate?

OBJECTIVES: The aim of this study was to collect consistent data on the efficacy and safety and evaluation hepatotoxicity of intravenous acetaminophen for the treatment of PDA in preterm infants. METHODS: This is an observational longitudinal prospective study on 46 preterm infants with PDA who trea...

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Autores principales: Bahrami, Reza, Ezzatabadi, Aida, Mehdizadegan, Nima, Mohammadi, Hamid, Amoozgar, Hamid, Edraki, Mohammadreza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7890839/
https://www.ncbi.nlm.nih.gov/pubmed/33596978
http://dx.doi.org/10.1186/s13052-020-00940-2
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author Bahrami, Reza
Ezzatabadi, Aida
Mehdizadegan, Nima
Mohammadi, Hamid
Amoozgar, Hamid
Edraki, Mohammadreza
author_facet Bahrami, Reza
Ezzatabadi, Aida
Mehdizadegan, Nima
Mohammadi, Hamid
Amoozgar, Hamid
Edraki, Mohammadreza
author_sort Bahrami, Reza
collection PubMed
description OBJECTIVES: The aim of this study was to collect consistent data on the efficacy and safety and evaluation hepatotoxicity of intravenous acetaminophen for the treatment of PDA in preterm infants. METHODS: This is an observational longitudinal prospective study on 46 preterm infants with PDA who treated with high dose of acetaminophen and evaluated with echocardiography and serum liver enzymes at Hafez and Zeinabiyeh hospitals from January 2016 to December 2019. RESULT: Forty-six preterm infants with PDA treated with intravenous acetaminophen. Rate of closure of PDA was 82.6. There was no significant difference after treatment regarding AST, ALT, Albumin, total and direct bilirubin (P value > 0.05) and no adverse side effects were observed in association with intravenous acetaminophen. CONCLUSION: High dose of acetaminophen is not more effective than that with standard doses although without hepatotoxic side effect for PDA closure.
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spelling pubmed-78908392021-02-22 Does high dose intravenous acetaminophen affect liver function for PDA closure in premature neonate? Bahrami, Reza Ezzatabadi, Aida Mehdizadegan, Nima Mohammadi, Hamid Amoozgar, Hamid Edraki, Mohammadreza Ital J Pediatr Research OBJECTIVES: The aim of this study was to collect consistent data on the efficacy and safety and evaluation hepatotoxicity of intravenous acetaminophen for the treatment of PDA in preterm infants. METHODS: This is an observational longitudinal prospective study on 46 preterm infants with PDA who treated with high dose of acetaminophen and evaluated with echocardiography and serum liver enzymes at Hafez and Zeinabiyeh hospitals from January 2016 to December 2019. RESULT: Forty-six preterm infants with PDA treated with intravenous acetaminophen. Rate of closure of PDA was 82.6. There was no significant difference after treatment regarding AST, ALT, Albumin, total and direct bilirubin (P value > 0.05) and no adverse side effects were observed in association with intravenous acetaminophen. CONCLUSION: High dose of acetaminophen is not more effective than that with standard doses although without hepatotoxic side effect for PDA closure. BioMed Central 2021-02-18 /pmc/articles/PMC7890839/ /pubmed/33596978 http://dx.doi.org/10.1186/s13052-020-00940-2 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Bahrami, Reza
Ezzatabadi, Aida
Mehdizadegan, Nima
Mohammadi, Hamid
Amoozgar, Hamid
Edraki, Mohammadreza
Does high dose intravenous acetaminophen affect liver function for PDA closure in premature neonate?
title Does high dose intravenous acetaminophen affect liver function for PDA closure in premature neonate?
title_full Does high dose intravenous acetaminophen affect liver function for PDA closure in premature neonate?
title_fullStr Does high dose intravenous acetaminophen affect liver function for PDA closure in premature neonate?
title_full_unstemmed Does high dose intravenous acetaminophen affect liver function for PDA closure in premature neonate?
title_short Does high dose intravenous acetaminophen affect liver function for PDA closure in premature neonate?
title_sort does high dose intravenous acetaminophen affect liver function for pda closure in premature neonate?
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7890839/
https://www.ncbi.nlm.nih.gov/pubmed/33596978
http://dx.doi.org/10.1186/s13052-020-00940-2
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