Turning off the alarm – Targeting alarmins and other epithelial mediators of allergic inflammation with biologics

Besides the major players IL-4, IL-13, IL-5, and IgE as targets for biologics, other mediators have been identified that are secreted by epithelial cells and act upstream in the cascade of allergic inflammation. Such are the alarmin IL-33 as well as TSLP and IL-5. The role of each cytokine in sensit...

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Detalles Bibliográficos
Autor principal: Albrecht, Melanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dustri-Verlag Dr. Karl Feistle 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7890934/
https://www.ncbi.nlm.nih.gov/pubmed/33615121
http://dx.doi.org/10.5414/ALX02194E
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author Albrecht, Melanie
author_facet Albrecht, Melanie
author_sort Albrecht, Melanie
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description Besides the major players IL-4, IL-13, IL-5, and IgE as targets for biologics, other mediators have been identified that are secreted by epithelial cells and act upstream in the cascade of allergic inflammation. Such are the alarmin IL-33 as well as TSLP and IL-5. The role of each cytokine in sensitization and effector phase of allergic inflammation and how development of biologics is ongoing in order to inhibit this pathomechanism will be described in the following article.
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spelling pubmed-78909342021-02-18 Turning off the alarm – Targeting alarmins and other epithelial mediators of allergic inflammation with biologics Albrecht, Melanie Allergol Select Review Article Besides the major players IL-4, IL-13, IL-5, and IgE as targets for biologics, other mediators have been identified that are secreted by epithelial cells and act upstream in the cascade of allergic inflammation. Such are the alarmin IL-33 as well as TSLP and IL-5. The role of each cytokine in sensitization and effector phase of allergic inflammation and how development of biologics is ongoing in order to inhibit this pathomechanism will be described in the following article. Dustri-Verlag Dr. Karl Feistle 2021-02-09 /pmc/articles/PMC7890934/ /pubmed/33615121 http://dx.doi.org/10.5414/ALX02194E Text en © Dustri-Verlag Dr. K. Feistle http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Albrecht, Melanie
Turning off the alarm – Targeting alarmins and other epithelial mediators of allergic inflammation with biologics
title Turning off the alarm – Targeting alarmins and other epithelial mediators of allergic inflammation with biologics
title_full Turning off the alarm – Targeting alarmins and other epithelial mediators of allergic inflammation with biologics
title_fullStr Turning off the alarm – Targeting alarmins and other epithelial mediators of allergic inflammation with biologics
title_full_unstemmed Turning off the alarm – Targeting alarmins and other epithelial mediators of allergic inflammation with biologics
title_short Turning off the alarm – Targeting alarmins and other epithelial mediators of allergic inflammation with biologics
title_sort turning off the alarm – targeting alarmins and other epithelial mediators of allergic inflammation with biologics
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7890934/
https://www.ncbi.nlm.nih.gov/pubmed/33615121
http://dx.doi.org/10.5414/ALX02194E
work_keys_str_mv AT albrechtmelanie turningoffthealarmtargetingalarminsandotherepithelialmediatorsofallergicinflammationwithbiologics

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