Cofilin: A Promising Protein Implicated in Cancer Metastasis and Apoptosis

Cofilin is an actin-binding protein that regulates filament dynamics and depolymerization. The over-expression of cofilin is observed in various cancers, cofilin promotes cancer metastasis by regulating cytoskeletal reorganization, lamellipodium formation and epithelial-to-mesenchymal transition. Cl...

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Autores principales: Xu, Jing, Huang, Yan, Zhao, Jimeng, Wu, Luyi, Qi, Qin, Liu, Yanan, Li, Guona, Li, Jing, Liu, Huirong, Wu, Huangan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7890941/
https://www.ncbi.nlm.nih.gov/pubmed/33614640
http://dx.doi.org/10.3389/fcell.2021.599065
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author Xu, Jing
Huang, Yan
Zhao, Jimeng
Wu, Luyi
Qi, Qin
Liu, Yanan
Li, Guona
Li, Jing
Liu, Huirong
Wu, Huangan
author_facet Xu, Jing
Huang, Yan
Zhao, Jimeng
Wu, Luyi
Qi, Qin
Liu, Yanan
Li, Guona
Li, Jing
Liu, Huirong
Wu, Huangan
author_sort Xu, Jing
collection PubMed
description Cofilin is an actin-binding protein that regulates filament dynamics and depolymerization. The over-expression of cofilin is observed in various cancers, cofilin promotes cancer metastasis by regulating cytoskeletal reorganization, lamellipodium formation and epithelial-to-mesenchymal transition. Clinical treatment of cancer regarding cofilin has been explored in aspects of tumor cells apoptosis and cofilin related miRNAs. This review addresses the structure and phosphorylation of cofilin and describes recent findings regarding the function of cofilin in regulating cancer metastasis and apoptosis in tumor cells.
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spelling pubmed-78909412021-02-19 Cofilin: A Promising Protein Implicated in Cancer Metastasis and Apoptosis Xu, Jing Huang, Yan Zhao, Jimeng Wu, Luyi Qi, Qin Liu, Yanan Li, Guona Li, Jing Liu, Huirong Wu, Huangan Front Cell Dev Biol Cell and Developmental Biology Cofilin is an actin-binding protein that regulates filament dynamics and depolymerization. The over-expression of cofilin is observed in various cancers, cofilin promotes cancer metastasis by regulating cytoskeletal reorganization, lamellipodium formation and epithelial-to-mesenchymal transition. Clinical treatment of cancer regarding cofilin has been explored in aspects of tumor cells apoptosis and cofilin related miRNAs. This review addresses the structure and phosphorylation of cofilin and describes recent findings regarding the function of cofilin in regulating cancer metastasis and apoptosis in tumor cells. Frontiers Media S.A. 2021-02-04 /pmc/articles/PMC7890941/ /pubmed/33614640 http://dx.doi.org/10.3389/fcell.2021.599065 Text en Copyright © 2021 Xu, Huang, Zhao, Wu, Qi, Liu, Li, Li, Liu and Wu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Xu, Jing
Huang, Yan
Zhao, Jimeng
Wu, Luyi
Qi, Qin
Liu, Yanan
Li, Guona
Li, Jing
Liu, Huirong
Wu, Huangan
Cofilin: A Promising Protein Implicated in Cancer Metastasis and Apoptosis
title Cofilin: A Promising Protein Implicated in Cancer Metastasis and Apoptosis
title_full Cofilin: A Promising Protein Implicated in Cancer Metastasis and Apoptosis
title_fullStr Cofilin: A Promising Protein Implicated in Cancer Metastasis and Apoptosis
title_full_unstemmed Cofilin: A Promising Protein Implicated in Cancer Metastasis and Apoptosis
title_short Cofilin: A Promising Protein Implicated in Cancer Metastasis and Apoptosis
title_sort cofilin: a promising protein implicated in cancer metastasis and apoptosis
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7890941/
https://www.ncbi.nlm.nih.gov/pubmed/33614640
http://dx.doi.org/10.3389/fcell.2021.599065
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