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Deletion of Socs3 in LysM(+) cells and Cx3cr1 resulted in age-dependent development of retinal microgliopathy

BACKGROUND: We generated a mouse model of primary microglial dysfunction by deleting two negative immune regulatory genes, Cx3cr1 and Socs3 (in LysM(+) cells). This study aimed to understand how primary microglial dysfunction impacts retinal neurons during aging. METHODS: The LysMCre-Socs3(fl/fl)Cx3...

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Detalles Bibliográficos
Autores principales:	Du, Xuan, Penalva, Rosana, Little, Karis, Kissenpfennig, Adrien, Chen, Mei, Xu, Heping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7891019/ https://www.ncbi.nlm.nih.gov/pubmed/33602265 http://dx.doi.org/10.1186/s13024-021-00432-9

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