Cancer therapy shapes the fitness landscape of clonal hematopoiesis

Acquired mutations are pervasive across normal tissues. However, our understanding of the processes that drive transformation of certain clones to cancer is limited. Here we study this phenomenon in the context of clonal hematopoiesis (CH) and the development of therapy-related myeloid neoplasms (tM...

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Detalles Bibliográficos
Autores principales: Bolton, Kelly L, Ptashkin, Ryan N, Gao, Teng, Braunstein, Lior, Devlin, Sean M, Kelly, Daniel, Patel, Minal, Berthon, Antonin, Syed, Aijazuddin, Yabe, Mariko, Coombs, Catherine C., Caltabellotta, Nicole M., Walsh, Mike, Offit, Kenneth, Stadler, Zsofia, Mandelker, Diana, Schulman, Jessica, Patel, Akshar, Philip, John, Bernard, Elsa, Gundem, Gunes, Ossa, Juan E Arango, Levine, Max, Martinez, Juan S Medina, Farnoud, Noushin, Glodzik, Dominik, Li, Sonya, Robson, Mark E, Lee, Choonsik, Pharoah, Paul D P, Stopsack, Konrad H, Spitzer, Barbara, Mantha, Simon, Fagin, James, Boucai, Laura, Gibson, Christopher J, Ebert, Benjamin L, Young, Andrew L, Druley, Todd, Takahashi, Koichi, Gillis, Nancy, Ball, Markus, Padron, Eric, Hyman, David M, Baselga, Jose, Norton, Larry, Gardos, Stuart, Klimek, Virginia M, Scher, Howard, Bajorin, Dean, Paraiso, Eder, Benayed, Ryma, Arcila, Maria E, Ladanyi, Marc, Solit, David B, Berger, Michael F, Tallman, Martin, Garcia-Closas, Montserrat, Chatterjee, Nilanjan, Diaz, Luis A, Levine, Ross L, Morton, Lindsay M, Zehir, Ahmet, Papaemmanuil, Elli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7891089/
https://www.ncbi.nlm.nih.gov/pubmed/33106634
http://dx.doi.org/10.1038/s41588-020-00710-0

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