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The Role of Frontal Assessment Battery and Frontal Lobe Single-Photon Emission Computed Tomography in the Differential Diagnosis of Progressive Supranuclear Palsy Variants and Corticobasal Syndrome—A Pilot Study

Progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS) are clinical syndromes classified as atypical parkinsonism. Due to their overlapping symptomatology, recent research shows the necessity of finding new methods of examination of these clinical entities. PSP is a heterogenic disease...

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Autores principales: Alster, Piotr, Migda, Bartosz, Madetko, Natalia, Duszyńska-Wąs, Karolina, Drzewińska, Agnieszka, Charzyńska, Ingeborga, Starczyński, Miłosz, Szepelska, Ada, Królicki, Leszek, Friedman, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7891101/
https://www.ncbi.nlm.nih.gov/pubmed/33613435
http://dx.doi.org/10.3389/fneur.2021.630153
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author Alster, Piotr
Migda, Bartosz
Madetko, Natalia
Duszyńska-Wąs, Karolina
Drzewińska, Agnieszka
Charzyńska, Ingeborga
Starczyński, Miłosz
Szepelska, Ada
Królicki, Leszek
Friedman, Andrzej
author_facet Alster, Piotr
Migda, Bartosz
Madetko, Natalia
Duszyńska-Wąs, Karolina
Drzewińska, Agnieszka
Charzyńska, Ingeborga
Starczyński, Miłosz
Szepelska, Ada
Królicki, Leszek
Friedman, Andrzej
author_sort Alster, Piotr
collection PubMed
description Progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS) are clinical syndromes classified as atypical parkinsonism. Due to their overlapping symptomatology, recent research shows the necessity of finding new methods of examination of these clinical entities. PSP is a heterogenic disease. PSP Richardson-Steele Syndrome (PSP-RS) and parkinsonism predominant (PSP-P) are the most common clinical variants of progressive supranuclear palsy syndrome. The different clinical course and life expectancy of PSP-RS and PSP-P stress the need of efficient examination in the early stages. The aim of the study was to evaluate the possible feasibility of the combined use of frontal assessment battery (FAB) and single-photon emission computed tomography (SPECT) in the differentiation of PSP-RS, PSP-P, and CBS. The findings show that FAB may be interpreted as a possible supplementary tool in the differential diagnosis of PSP-P and PSP-RS. The differences in SPECT are less pronounced. The study does not show any advantages of performing combined frontal SPECT and FAB in the differential examination of PSP and CBS. Moreover, PSP-RS and CBS, in a detailed evaluation of the frontal lobe, do not show any significant differences. This is a relatively small study which, however, highlights the relevant features of clinical examination of these rare entities.
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spelling pubmed-78911012021-02-19 The Role of Frontal Assessment Battery and Frontal Lobe Single-Photon Emission Computed Tomography in the Differential Diagnosis of Progressive Supranuclear Palsy Variants and Corticobasal Syndrome—A Pilot Study Alster, Piotr Migda, Bartosz Madetko, Natalia Duszyńska-Wąs, Karolina Drzewińska, Agnieszka Charzyńska, Ingeborga Starczyński, Miłosz Szepelska, Ada Królicki, Leszek Friedman, Andrzej Front Neurol Neurology Progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS) are clinical syndromes classified as atypical parkinsonism. Due to their overlapping symptomatology, recent research shows the necessity of finding new methods of examination of these clinical entities. PSP is a heterogenic disease. PSP Richardson-Steele Syndrome (PSP-RS) and parkinsonism predominant (PSP-P) are the most common clinical variants of progressive supranuclear palsy syndrome. The different clinical course and life expectancy of PSP-RS and PSP-P stress the need of efficient examination in the early stages. The aim of the study was to evaluate the possible feasibility of the combined use of frontal assessment battery (FAB) and single-photon emission computed tomography (SPECT) in the differentiation of PSP-RS, PSP-P, and CBS. The findings show that FAB may be interpreted as a possible supplementary tool in the differential diagnosis of PSP-P and PSP-RS. The differences in SPECT are less pronounced. The study does not show any advantages of performing combined frontal SPECT and FAB in the differential examination of PSP and CBS. Moreover, PSP-RS and CBS, in a detailed evaluation of the frontal lobe, do not show any significant differences. This is a relatively small study which, however, highlights the relevant features of clinical examination of these rare entities. Frontiers Media S.A. 2021-02-04 /pmc/articles/PMC7891101/ /pubmed/33613435 http://dx.doi.org/10.3389/fneur.2021.630153 Text en Copyright © 2021 Alster, Migda, Madetko, Duszyńska-Wąs, Drzewińska, Charzyńska, Starczyński, Szepelska, Królicki and Friedman. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Alster, Piotr
Migda, Bartosz
Madetko, Natalia
Duszyńska-Wąs, Karolina
Drzewińska, Agnieszka
Charzyńska, Ingeborga
Starczyński, Miłosz
Szepelska, Ada
Królicki, Leszek
Friedman, Andrzej
The Role of Frontal Assessment Battery and Frontal Lobe Single-Photon Emission Computed Tomography in the Differential Diagnosis of Progressive Supranuclear Palsy Variants and Corticobasal Syndrome—A Pilot Study
title The Role of Frontal Assessment Battery and Frontal Lobe Single-Photon Emission Computed Tomography in the Differential Diagnosis of Progressive Supranuclear Palsy Variants and Corticobasal Syndrome—A Pilot Study
title_full The Role of Frontal Assessment Battery and Frontal Lobe Single-Photon Emission Computed Tomography in the Differential Diagnosis of Progressive Supranuclear Palsy Variants and Corticobasal Syndrome—A Pilot Study
title_fullStr The Role of Frontal Assessment Battery and Frontal Lobe Single-Photon Emission Computed Tomography in the Differential Diagnosis of Progressive Supranuclear Palsy Variants and Corticobasal Syndrome—A Pilot Study
title_full_unstemmed The Role of Frontal Assessment Battery and Frontal Lobe Single-Photon Emission Computed Tomography in the Differential Diagnosis of Progressive Supranuclear Palsy Variants and Corticobasal Syndrome—A Pilot Study
title_short The Role of Frontal Assessment Battery and Frontal Lobe Single-Photon Emission Computed Tomography in the Differential Diagnosis of Progressive Supranuclear Palsy Variants and Corticobasal Syndrome—A Pilot Study
title_sort role of frontal assessment battery and frontal lobe single-photon emission computed tomography in the differential diagnosis of progressive supranuclear palsy variants and corticobasal syndrome—a pilot study
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7891101/
https://www.ncbi.nlm.nih.gov/pubmed/33613435
http://dx.doi.org/10.3389/fneur.2021.630153
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