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Alterations of Brain Structural Network Connectivity in Type 2 Diabetes Mellitus Patients With Mild Cognitive Impairment

Patients with type 2 diabetes mellitus (T2DM) are highly susceptible to developing dementia, especially for those with mild cognitive impairment (MCI), but its underlying cause is still unclear. This study aims to investigate the early detection of white matter structural network changes in T2DM pat...

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Autores principales: Li, Chang, Zhang, Jingna, Qiu, Mingguo, Liu, Kaijun, Li, Yang, Zuo, Zhiwei, Yin, Xuntao, Lai, Yuqi, Fang, Jingqin, Tong, Haipeng, Guo, Yu, Wang, Jian, Chen, Xiao, Xiong, Kunlin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7891182/
https://www.ncbi.nlm.nih.gov/pubmed/33613263
http://dx.doi.org/10.3389/fnagi.2020.615048
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author Li, Chang
Zhang, Jingna
Qiu, Mingguo
Liu, Kaijun
Li, Yang
Zuo, Zhiwei
Yin, Xuntao
Lai, Yuqi
Fang, Jingqin
Tong, Haipeng
Guo, Yu
Wang, Jian
Chen, Xiao
Xiong, Kunlin
author_facet Li, Chang
Zhang, Jingna
Qiu, Mingguo
Liu, Kaijun
Li, Yang
Zuo, Zhiwei
Yin, Xuntao
Lai, Yuqi
Fang, Jingqin
Tong, Haipeng
Guo, Yu
Wang, Jian
Chen, Xiao
Xiong, Kunlin
author_sort Li, Chang
collection PubMed
description Patients with type 2 diabetes mellitus (T2DM) are highly susceptible to developing dementia, especially for those with mild cognitive impairment (MCI), but its underlying cause is still unclear. This study aims to investigate the early detection of white matter structural network changes in T2DM patients with MCI and assess the relationship between cognitive impairment and structural network alterations in T2DM patients. In this study, we performed a battery of neuropsychological tests and diffusion tensor MRI in 30 T2MD-MCI patients, 30 T2DM patients with normal cognition (T2DM-NC) and 30 age-, sex-, and education-matched healthy control (HC) individuals. Cognitive performance exhibited obvious differences among the three groups. The structural network was significantly disrupted in both global and regional levels in T2DM patients. The T2DM-MCI group showed more severe impairment of global network efficiency, and lower nodal efficiency and fewer connections within multiple regions like the limbic system, basal ganglia, and several cortical structures. Moreover, a subnetwork impaired in T2DM-MCI patients was characterized by cortical-limbic fibers, and commissural fibers and pathways within the frontal, temporal, and occipital lobes. These altered global and nodal parameters were significantly correlated with cognitive function in T2DM-MCI patients. In particular, executive dysfunction and working memory impairment in T2DM-MCI patients correlated with nodal efficiency in the right opercular part and triangular part of the inferior frontal gyrus, which indicated that white matter disruption in these regions may act as potential biomarkers for T2DM-associated MCI detection. Our investigation provides a novel insight into the neuropathological effects of white matter network disruption on cognition impairments induced by T2DM.
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spelling pubmed-78911822021-02-19 Alterations of Brain Structural Network Connectivity in Type 2 Diabetes Mellitus Patients With Mild Cognitive Impairment Li, Chang Zhang, Jingna Qiu, Mingguo Liu, Kaijun Li, Yang Zuo, Zhiwei Yin, Xuntao Lai, Yuqi Fang, Jingqin Tong, Haipeng Guo, Yu Wang, Jian Chen, Xiao Xiong, Kunlin Front Aging Neurosci Neuroscience Patients with type 2 diabetes mellitus (T2DM) are highly susceptible to developing dementia, especially for those with mild cognitive impairment (MCI), but its underlying cause is still unclear. This study aims to investigate the early detection of white matter structural network changes in T2DM patients with MCI and assess the relationship between cognitive impairment and structural network alterations in T2DM patients. In this study, we performed a battery of neuropsychological tests and diffusion tensor MRI in 30 T2MD-MCI patients, 30 T2DM patients with normal cognition (T2DM-NC) and 30 age-, sex-, and education-matched healthy control (HC) individuals. Cognitive performance exhibited obvious differences among the three groups. The structural network was significantly disrupted in both global and regional levels in T2DM patients. The T2DM-MCI group showed more severe impairment of global network efficiency, and lower nodal efficiency and fewer connections within multiple regions like the limbic system, basal ganglia, and several cortical structures. Moreover, a subnetwork impaired in T2DM-MCI patients was characterized by cortical-limbic fibers, and commissural fibers and pathways within the frontal, temporal, and occipital lobes. These altered global and nodal parameters were significantly correlated with cognitive function in T2DM-MCI patients. In particular, executive dysfunction and working memory impairment in T2DM-MCI patients correlated with nodal efficiency in the right opercular part and triangular part of the inferior frontal gyrus, which indicated that white matter disruption in these regions may act as potential biomarkers for T2DM-associated MCI detection. Our investigation provides a novel insight into the neuropathological effects of white matter network disruption on cognition impairments induced by T2DM. Frontiers Media S.A. 2021-02-04 /pmc/articles/PMC7891182/ /pubmed/33613263 http://dx.doi.org/10.3389/fnagi.2020.615048 Text en Copyright © 2021 Li, Zhang, Qiu, Liu, Li, Zuo, Yin, Lai, Fang, Tong, Guo, Wang, Chen and Xiong. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Li, Chang
Zhang, Jingna
Qiu, Mingguo
Liu, Kaijun
Li, Yang
Zuo, Zhiwei
Yin, Xuntao
Lai, Yuqi
Fang, Jingqin
Tong, Haipeng
Guo, Yu
Wang, Jian
Chen, Xiao
Xiong, Kunlin
Alterations of Brain Structural Network Connectivity in Type 2 Diabetes Mellitus Patients With Mild Cognitive Impairment
title Alterations of Brain Structural Network Connectivity in Type 2 Diabetes Mellitus Patients With Mild Cognitive Impairment
title_full Alterations of Brain Structural Network Connectivity in Type 2 Diabetes Mellitus Patients With Mild Cognitive Impairment
title_fullStr Alterations of Brain Structural Network Connectivity in Type 2 Diabetes Mellitus Patients With Mild Cognitive Impairment
title_full_unstemmed Alterations of Brain Structural Network Connectivity in Type 2 Diabetes Mellitus Patients With Mild Cognitive Impairment
title_short Alterations of Brain Structural Network Connectivity in Type 2 Diabetes Mellitus Patients With Mild Cognitive Impairment
title_sort alterations of brain structural network connectivity in type 2 diabetes mellitus patients with mild cognitive impairment
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7891182/
https://www.ncbi.nlm.nih.gov/pubmed/33613263
http://dx.doi.org/10.3389/fnagi.2020.615048
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