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Short‐term inhibition of SARS‐CoV‐2 by hydrogen peroxide in persistent nasopharyngeal carriers
Asymptomatic and convalescent coronavirus disease 2019 (COVID‐19) subjects may carry severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) for months in their upper respiratory ways. Desiring to permanently clean the mucosal surfaces, we investigated the chemical agents that fit to rapidly de...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7891345/ https://www.ncbi.nlm.nih.gov/pubmed/32881014 http://dx.doi.org/10.1002/jmv.26485 |
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author | Capetti, Amedeo F. Borgonovo, Fabio Morena, Valentina Lupo, Angelica Cossu, Maria Vittoria Passerini, Matteo Dedivitiis, Gianfranco Rizzardini, Giuliano |
author_facet | Capetti, Amedeo F. Borgonovo, Fabio Morena, Valentina Lupo, Angelica Cossu, Maria Vittoria Passerini, Matteo Dedivitiis, Gianfranco Rizzardini, Giuliano |
author_sort | Capetti, Amedeo F. |
collection | PubMed |
description | Asymptomatic and convalescent coronavirus disease 2019 (COVID‐19) subjects may carry severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) for months in their upper respiratory ways. Desiring to permanently clean the mucosal surfaces, we investigated the chemical agents that fit to rapidly degrade the virus. Among these, hydrogen peroxide, initially tested by two of us for tolerability, showed both good performance and acceptable side effects (burning sensation for 15–20 s). We contacted circles of family physicians and the ATS Milano (Territorial Assistance and Prevention Service), and we tested this procedure on eight persistent carriers of SARS‐CoV‐2, performing swabs before the procedure and after it until the reappearance of the virus or until 14 days (the incubation period), keeping the surfaces clean with a hypertonic solution. Our patients had a median time from exposure or symptom onset of 111 days, and three had relapsed after being declared “cured” (two consecutive negative swabs after quarantine). One patient had a baseline negative swab and was excluded, and two successfully ended the 14 days' course, four suppressed viral elimination for 72 h, and one for 48 h, all rebounding to weak positive (cycle thresholds above 24). Although temporarily effective, such measures may have some place in the control of viral shedding to protect the most fragile subjects. |
format | Online Article Text |
id | pubmed-7891345 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78913452021-03-02 Short‐term inhibition of SARS‐CoV‐2 by hydrogen peroxide in persistent nasopharyngeal carriers Capetti, Amedeo F. Borgonovo, Fabio Morena, Valentina Lupo, Angelica Cossu, Maria Vittoria Passerini, Matteo Dedivitiis, Gianfranco Rizzardini, Giuliano J Med Virol Short Communications Asymptomatic and convalescent coronavirus disease 2019 (COVID‐19) subjects may carry severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) for months in their upper respiratory ways. Desiring to permanently clean the mucosal surfaces, we investigated the chemical agents that fit to rapidly degrade the virus. Among these, hydrogen peroxide, initially tested by two of us for tolerability, showed both good performance and acceptable side effects (burning sensation for 15–20 s). We contacted circles of family physicians and the ATS Milano (Territorial Assistance and Prevention Service), and we tested this procedure on eight persistent carriers of SARS‐CoV‐2, performing swabs before the procedure and after it until the reappearance of the virus or until 14 days (the incubation period), keeping the surfaces clean with a hypertonic solution. Our patients had a median time from exposure or symptom onset of 111 days, and three had relapsed after being declared “cured” (two consecutive negative swabs after quarantine). One patient had a baseline negative swab and was excluded, and two successfully ended the 14 days' course, four suppressed viral elimination for 72 h, and one for 48 h, all rebounding to weak positive (cycle thresholds above 24). Although temporarily effective, such measures may have some place in the control of viral shedding to protect the most fragile subjects. John Wiley and Sons Inc. 2020-09-24 2021-03 /pmc/articles/PMC7891345/ /pubmed/32881014 http://dx.doi.org/10.1002/jmv.26485 Text en © 2020 The Authors. Journal of Medical Virology published by Wiley Periodicals LLC This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Communications Capetti, Amedeo F. Borgonovo, Fabio Morena, Valentina Lupo, Angelica Cossu, Maria Vittoria Passerini, Matteo Dedivitiis, Gianfranco Rizzardini, Giuliano Short‐term inhibition of SARS‐CoV‐2 by hydrogen peroxide in persistent nasopharyngeal carriers |
title | Short‐term inhibition of SARS‐CoV‐2 by hydrogen peroxide in persistent nasopharyngeal carriers |
title_full | Short‐term inhibition of SARS‐CoV‐2 by hydrogen peroxide in persistent nasopharyngeal carriers |
title_fullStr | Short‐term inhibition of SARS‐CoV‐2 by hydrogen peroxide in persistent nasopharyngeal carriers |
title_full_unstemmed | Short‐term inhibition of SARS‐CoV‐2 by hydrogen peroxide in persistent nasopharyngeal carriers |
title_short | Short‐term inhibition of SARS‐CoV‐2 by hydrogen peroxide in persistent nasopharyngeal carriers |
title_sort | short‐term inhibition of sars‐cov‐2 by hydrogen peroxide in persistent nasopharyngeal carriers |
topic | Short Communications |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7891345/ https://www.ncbi.nlm.nih.gov/pubmed/32881014 http://dx.doi.org/10.1002/jmv.26485 |
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