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A systematic review evaluating the influence of incisional Negative Pressure Wound Therapy on scarring
Pathological scars can result in functional impairment, disfigurement, a psychological burden, itch, and even chronic pain. We conducted a systematic review to investigate the influence of incisional Negative Pressure Wound Therapy (iNPWT) on scarring. PubMed, EMBASE and CINAHL were searched for pre...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7891404/ https://www.ncbi.nlm.nih.gov/pubmed/32789902 http://dx.doi.org/10.1111/wrr.12858 |
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author | Zwanenburg, Pieter R. Timmermans, Floyd W. Timmer, Allard S. Middelkoop, Esther Tol, Berend T. Lapid, Oren Obdeijn, Miryam C. Gans, Sarah L. Boermeester, Marja A. |
author_facet | Zwanenburg, Pieter R. Timmermans, Floyd W. Timmer, Allard S. Middelkoop, Esther Tol, Berend T. Lapid, Oren Obdeijn, Miryam C. Gans, Sarah L. Boermeester, Marja A. |
author_sort | Zwanenburg, Pieter R. |
collection | PubMed |
description | Pathological scars can result in functional impairment, disfigurement, a psychological burden, itch, and even chronic pain. We conducted a systematic review to investigate the influence of incisional Negative Pressure Wound Therapy (iNPWT) on scarring. PubMed, EMBASE and CINAHL were searched for preclinical and clinical comparative studies that investigated the influence of iNPWT on scarring‐related outcomes. Individual studies were assessed using the OHAT Risk of Bias Rating Tool for Human and Animal studies. The body of evidence was rated using OHAT methodology. Six preclinical studies and nine clinical studies (377 patients) were identified. Preclinical studies suggested that iNPWT reduced lateral tension on incisions, increased wound strength, and reduced scar width upon histological assessment. Two clinical studies reported improved patient‐reported scar satisfaction as measured with the PSAS (1 year after surgery), POSAS, and a VAS (both 42, 90, and 180 days after surgery). Five clinical studies reported improved observer‐reported scar satisfaction as measured with the VSS, SBSES, OSAS, MSS, VAS, and POSAS (7, 15, 30, 42, 90, 180, and 365 days after surgery). Three clinical studies did not detect significant differences at any point in time (POSAS, VAS, and NRS). Because of imprecision concerns, a moderate level of evidence was identified using OHAT methodology. Preclinical as well as clinical evidence indicates a beneficial influence of iNPWT on scarring. Moderate level evidence indicates that iNPWT decreases scar width and improves patient and observer‐reported scar satisfaction. |
format | Online Article Text |
id | pubmed-7891404 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78914042021-03-02 A systematic review evaluating the influence of incisional Negative Pressure Wound Therapy on scarring Zwanenburg, Pieter R. Timmermans, Floyd W. Timmer, Allard S. Middelkoop, Esther Tol, Berend T. Lapid, Oren Obdeijn, Miryam C. Gans, Sarah L. Boermeester, Marja A. Wound Repair Regen Systematic Review Pathological scars can result in functional impairment, disfigurement, a psychological burden, itch, and even chronic pain. We conducted a systematic review to investigate the influence of incisional Negative Pressure Wound Therapy (iNPWT) on scarring. PubMed, EMBASE and CINAHL were searched for preclinical and clinical comparative studies that investigated the influence of iNPWT on scarring‐related outcomes. Individual studies were assessed using the OHAT Risk of Bias Rating Tool for Human and Animal studies. The body of evidence was rated using OHAT methodology. Six preclinical studies and nine clinical studies (377 patients) were identified. Preclinical studies suggested that iNPWT reduced lateral tension on incisions, increased wound strength, and reduced scar width upon histological assessment. Two clinical studies reported improved patient‐reported scar satisfaction as measured with the PSAS (1 year after surgery), POSAS, and a VAS (both 42, 90, and 180 days after surgery). Five clinical studies reported improved observer‐reported scar satisfaction as measured with the VSS, SBSES, OSAS, MSS, VAS, and POSAS (7, 15, 30, 42, 90, 180, and 365 days after surgery). Three clinical studies did not detect significant differences at any point in time (POSAS, VAS, and NRS). Because of imprecision concerns, a moderate level of evidence was identified using OHAT methodology. Preclinical as well as clinical evidence indicates a beneficial influence of iNPWT on scarring. Moderate level evidence indicates that iNPWT decreases scar width and improves patient and observer‐reported scar satisfaction. John Wiley & Sons, Inc. 2020-08-21 2021 /pmc/articles/PMC7891404/ /pubmed/32789902 http://dx.doi.org/10.1111/wrr.12858 Text en © 2020 The Authors. Wound Repair and Regeneration published by Wiley Periodicals LLC on behalf of The Wound Healing Society. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Systematic Review Zwanenburg, Pieter R. Timmermans, Floyd W. Timmer, Allard S. Middelkoop, Esther Tol, Berend T. Lapid, Oren Obdeijn, Miryam C. Gans, Sarah L. Boermeester, Marja A. A systematic review evaluating the influence of incisional Negative Pressure Wound Therapy on scarring |
title | A systematic review evaluating the influence of incisional Negative Pressure Wound Therapy on scarring |
title_full | A systematic review evaluating the influence of incisional Negative Pressure Wound Therapy on scarring |
title_fullStr | A systematic review evaluating the influence of incisional Negative Pressure Wound Therapy on scarring |
title_full_unstemmed | A systematic review evaluating the influence of incisional Negative Pressure Wound Therapy on scarring |
title_short | A systematic review evaluating the influence of incisional Negative Pressure Wound Therapy on scarring |
title_sort | systematic review evaluating the influence of incisional negative pressure wound therapy on scarring |
topic | Systematic Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7891404/ https://www.ncbi.nlm.nih.gov/pubmed/32789902 http://dx.doi.org/10.1111/wrr.12858 |
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