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Differential diagnosis of coronavirus disease 2019 pneumonia or influenza A pneumonia by clinical characteristics and laboratory findings
BACKGROUND: Pneumonia caused by the 2019 novel Coronavirus (COVID‐2019) shares overlapping signs and symptoms, laboratory findings, imaging features with influenza A pneumonia. We aimed to identify their clinical characteristics to help early diagnosis. METHODS: We retrospectively retrieved data for...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7891506/ https://www.ncbi.nlm.nih.gov/pubmed/33576536 http://dx.doi.org/10.1002/jcla.23685 |
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author | Lv, Ding‐feng Ying, Qi‐ming He, Yi‐wen Liang, Jun Zhang, Ji‐hong Lu, Bei‐bei Qian, Guo‐qing Chu, Jin‐guo Weng, Xing‐bei Chen, Xue‐qin Mu, Qi‐tian |
author_facet | Lv, Ding‐feng Ying, Qi‐ming He, Yi‐wen Liang, Jun Zhang, Ji‐hong Lu, Bei‐bei Qian, Guo‐qing Chu, Jin‐guo Weng, Xing‐bei Chen, Xue‐qin Mu, Qi‐tian |
author_sort | Lv, Ding‐feng |
collection | PubMed |
description | BACKGROUND: Pneumonia caused by the 2019 novel Coronavirus (COVID‐2019) shares overlapping signs and symptoms, laboratory findings, imaging features with influenza A pneumonia. We aimed to identify their clinical characteristics to help early diagnosis. METHODS: We retrospectively retrieved data for laboratory‐confirmed patients admitted with COVID‐19–induced or influenza A–induced pneumonia from electronic medical records in Ningbo First Hospital, China. We recorded patients' epidemiological and clinical features, as well as radiologic and laboratory findings. RESULTS: The median age of influenza A cohort was higher and it exhibited higher temperature and higher proportion of pleural effusion. COVID‐19 cohort exhibited higher proportions of fatigue, diarrhea and ground‐glass opacity and higher levels of lymphocyte percentage, absolute lymphocyte count, red‐cell count, hemoglobin and albumin and presented lower levels of monocytes, c‐reactive protein, aspartate aminotransferase, alkaline phosphatase, serum creatinine. Multivariate logistic regression analyses showed that fatigue, ground‐glass opacity, and higher level of albumin were independent risk factors for COVID‐19 pneumonia, while older age, higher temperature, and higher level of monocyte count were independent risk factors for influenza A pneumonia. CONCLUSIONS: In terms of COVID‐19 pneumonia and influenza A pneumonia, fatigue, ground‐glass opacity, and higher level of albumin tend to be helpful for diagnosis of COVID‐19 pneumonia, while older age, higher temperature, and higher level of monocyte count tend to be helpful for the diagnosis of influenza A pneumonia. |
format | Online Article Text |
id | pubmed-7891506 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78915062021-03-10 Differential diagnosis of coronavirus disease 2019 pneumonia or influenza A pneumonia by clinical characteristics and laboratory findings Lv, Ding‐feng Ying, Qi‐ming He, Yi‐wen Liang, Jun Zhang, Ji‐hong Lu, Bei‐bei Qian, Guo‐qing Chu, Jin‐guo Weng, Xing‐bei Chen, Xue‐qin Mu, Qi‐tian J Clin Lab Anal Research Articles BACKGROUND: Pneumonia caused by the 2019 novel Coronavirus (COVID‐2019) shares overlapping signs and symptoms, laboratory findings, imaging features with influenza A pneumonia. We aimed to identify their clinical characteristics to help early diagnosis. METHODS: We retrospectively retrieved data for laboratory‐confirmed patients admitted with COVID‐19–induced or influenza A–induced pneumonia from electronic medical records in Ningbo First Hospital, China. We recorded patients' epidemiological and clinical features, as well as radiologic and laboratory findings. RESULTS: The median age of influenza A cohort was higher and it exhibited higher temperature and higher proportion of pleural effusion. COVID‐19 cohort exhibited higher proportions of fatigue, diarrhea and ground‐glass opacity and higher levels of lymphocyte percentage, absolute lymphocyte count, red‐cell count, hemoglobin and albumin and presented lower levels of monocytes, c‐reactive protein, aspartate aminotransferase, alkaline phosphatase, serum creatinine. Multivariate logistic regression analyses showed that fatigue, ground‐glass opacity, and higher level of albumin were independent risk factors for COVID‐19 pneumonia, while older age, higher temperature, and higher level of monocyte count were independent risk factors for influenza A pneumonia. CONCLUSIONS: In terms of COVID‐19 pneumonia and influenza A pneumonia, fatigue, ground‐glass opacity, and higher level of albumin tend to be helpful for diagnosis of COVID‐19 pneumonia, while older age, higher temperature, and higher level of monocyte count tend to be helpful for the diagnosis of influenza A pneumonia. John Wiley and Sons Inc. 2021-02-12 /pmc/articles/PMC7891506/ /pubmed/33576536 http://dx.doi.org/10.1002/jcla.23685 Text en © 2021 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Research Articles Lv, Ding‐feng Ying, Qi‐ming He, Yi‐wen Liang, Jun Zhang, Ji‐hong Lu, Bei‐bei Qian, Guo‐qing Chu, Jin‐guo Weng, Xing‐bei Chen, Xue‐qin Mu, Qi‐tian Differential diagnosis of coronavirus disease 2019 pneumonia or influenza A pneumonia by clinical characteristics and laboratory findings |
title | Differential diagnosis of coronavirus disease 2019 pneumonia or influenza A pneumonia by clinical characteristics and laboratory findings |
title_full | Differential diagnosis of coronavirus disease 2019 pneumonia or influenza A pneumonia by clinical characteristics and laboratory findings |
title_fullStr | Differential diagnosis of coronavirus disease 2019 pneumonia or influenza A pneumonia by clinical characteristics and laboratory findings |
title_full_unstemmed | Differential diagnosis of coronavirus disease 2019 pneumonia or influenza A pneumonia by clinical characteristics and laboratory findings |
title_short | Differential diagnosis of coronavirus disease 2019 pneumonia or influenza A pneumonia by clinical characteristics and laboratory findings |
title_sort | differential diagnosis of coronavirus disease 2019 pneumonia or influenza a pneumonia by clinical characteristics and laboratory findings |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7891506/ https://www.ncbi.nlm.nih.gov/pubmed/33576536 http://dx.doi.org/10.1002/jcla.23685 |
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