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Reliability and Reproducibility of Neuromelanin‐Sensitive Imaging of the Substantia Nigra: A Comparison of Three Different Sequences
BACKGROUND: Neuromelanin‐sensitive MRI (NM‐MRI) of the substantia nigra provides a noninvasive way to acquire an indirect measure of dopamine functioning. Despite the potential of NM‐MRI as a candidate biomarker for dopaminergic pathology, studies about its reproducibility are sparse. PURPOSE: To as...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7891576/ https://www.ncbi.nlm.nih.gov/pubmed/33037730 http://dx.doi.org/10.1002/jmri.27384 |
Sumario: | BACKGROUND: Neuromelanin‐sensitive MRI (NM‐MRI) of the substantia nigra provides a noninvasive way to acquire an indirect measure of dopamine functioning. Despite the potential of NM‐MRI as a candidate biomarker for dopaminergic pathology, studies about its reproducibility are sparse. PURPOSE: To assess the test–retest reproducibility of three commonly used NM‐MRI sequences and evaluate three analysis methods. STUDY TYPE: Prospective study. POPULATION: A total of 11 healthy participants age between 20–27 years. FIELD STRENGTH/SEQUENCE: 3.0T; NM‐MRI gradient recalled echo (GRE) with magnetization transfer (MT) pulse; NM‐MRI turbo spin echo (TSE) with MT pulse; NM‐MRI TSE without MT pulse. ASSESSMENT: Participants were scanned twice with a 3‐week interval. Manual analysis, threshold analysis, and voxelwise analysis were performed for volume and contrast ratio (CR) measurements. STATISTICAL TESTS: Intraclass correlation coefficients (ICCs) were calculated for test–retest and inter‐ and intrarater variability. RESULTS: The GRE sequence achieved the highest contrast and lowest variability (4.9–5.7%) and showed substantial to almost perfect test–retest ICC (0.72–0.90) for CR measurements. For volume measurements, the manual analysis showed a higher variability (10.7–17.9%) and scored lower test–retest ICCs (–0.13–0.73) than the other analysis methods. The threshold analysis showed higher test–retest ICC (0.77) than the manual analysis for the volume measurements. DATA CONCLUSION: NM‐MRI is a highly reproducible measure, especially when using the GRE sequence and CR measurements. Volume measurements appear to be more sensitive to inter/intrarater variability and variability in placement and orientation of the NM‐MRI slab. The threshold analysis appears to be the best alternative for volume analysis. LEVEL OF EVIDENCE: 2 TECHNICAL EFFICACY STAGE: 1 |
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