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Increase in treatment of retinopathy of prematurity in the Netherlands from 2010 to 2017

PURPOSE: Compare patients treated for Retinopathy of Prematurity (ROP) in two consecutive periods. METHODS: Retrospective inventory of anonymized neonatal and ophthalmological data of all patients treated for ROP from 2010 to 2017 in the Netherlands, subdivided in period (P)1: 1‐1‐2010 to 31‐3‐2013...

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Autores principales: Trzcionkowska, Kasia, Vehmeijer, Wouter B.H.J., Kerkhoff, Frank T., Bauer, Noel J.C., Bennebroek, Carlien A.M., Dijk, Peter H., Dijkman, Koen P., van den Dungen, Frank A.M., Eggink, Cathrien A., Feenstra, Robert P.G., Groenendaal, Floris, van Heijst, Arno F., van der Hoeven, Mark A.H.B.M., Kornelisse, Rene F., Kraal‐Biezen, Elke, Lopriore, Enrico, Onland, Wes, Renardel de Lavalette, Victor W., van Rijn, Laurentius J., Schuerman, Frank A.B.A., Simonsz, Huibert J., Voskuil‐Kerkhof, Elsbeth S.M., Witlox, Ruben S.G.M., Termote, Jacqueline U.M., Schalij‐Delfos, Nicoline E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7891652/
https://www.ncbi.nlm.nih.gov/pubmed/32701185
http://dx.doi.org/10.1111/aos.14501
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author Trzcionkowska, Kasia
Vehmeijer, Wouter B.H.J.
Kerkhoff, Frank T.
Bauer, Noel J.C.
Bennebroek, Carlien A.M.
Dijk, Peter H.
Dijkman, Koen P.
van den Dungen, Frank A.M.
Eggink, Cathrien A.
Feenstra, Robert P.G.
Groenendaal, Floris
van Heijst, Arno F.
van der Hoeven, Mark A.H.B.M.
Kornelisse, Rene F.
Kraal‐Biezen, Elke
Lopriore, Enrico
Onland, Wes
Renardel de Lavalette, Victor W.
van Rijn, Laurentius J.
Schuerman, Frank A.B.A.
Simonsz, Huibert J.
Voskuil‐Kerkhof, Elsbeth S.M.
Witlox, Ruben S.G.M.
Termote, Jacqueline U.M.
Schalij‐Delfos, Nicoline E.
author_facet Trzcionkowska, Kasia
Vehmeijer, Wouter B.H.J.
Kerkhoff, Frank T.
Bauer, Noel J.C.
Bennebroek, Carlien A.M.
Dijk, Peter H.
Dijkman, Koen P.
van den Dungen, Frank A.M.
Eggink, Cathrien A.
Feenstra, Robert P.G.
Groenendaal, Floris
van Heijst, Arno F.
van der Hoeven, Mark A.H.B.M.
Kornelisse, Rene F.
Kraal‐Biezen, Elke
Lopriore, Enrico
Onland, Wes
Renardel de Lavalette, Victor W.
van Rijn, Laurentius J.
Schuerman, Frank A.B.A.
Simonsz, Huibert J.
Voskuil‐Kerkhof, Elsbeth S.M.
Witlox, Ruben S.G.M.
Termote, Jacqueline U.M.
Schalij‐Delfos, Nicoline E.
author_sort Trzcionkowska, Kasia
collection PubMed
description PURPOSE: Compare patients treated for Retinopathy of Prematurity (ROP) in two consecutive periods. METHODS: Retrospective inventory of anonymized neonatal and ophthalmological data of all patients treated for ROP from 2010 to 2017 in the Netherlands, subdivided in period (P)1: 1‐1‐2010 to 31‐3‐2013 and P2: 1‐4‐2013 to 31‐12‐2016. Treatment characteristics, adherence to early treatment for ROP (ETROP) criteria, outcome of treatment and changes in neonatal parameters and policy of care were compared. RESULTS: Overall 196 infants were included, 57 infants (113 eyes) in P1 and 139 (275 eyes) in P2, indicating a 2.1‐fold increase in ROP treatment. No differences were found in mean gestational age (GA) (25.9 ± 1.7 versus 26.0 ± 1.7 weeks, p = 0.711), mean birth weight (791 ± 311 versus 764 ± 204 grams, p = 0.967) and other neonatal risk factors for ROP. In P2, the number of premature infants born <25 weeks increased by factor 1.23 and higher oxygen saturation levels were aimed at in most centres. At treatment decision, 59.6% (P1) versus 83.5% (P2) (p = 0.263) infants were classified as Type 1 ROP (ETROP classification). Infants were treated with laser photocoagulation (98 versus 96%) and intravitreal bevacizumab (2 versus 4%). Retreatment was necessary in 10 versus 21 (p = 0.160). Retinal detachment developed in 6 versus 13 infants (p = 0.791) of which 2 versus 6 bilateral (p = 0.599). CONCLUSION: In period 2, the number of infants treated according to the ETROP criteria (Type 1) increased, the number of ROP treatments, retinal detachments and retreatments doubled and the absolute number of retinal detachments increased. Neonatal data did not provide a decisive explanation, although changes in neonatal policy were reported.
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spelling pubmed-78916522021-03-02 Increase in treatment of retinopathy of prematurity in the Netherlands from 2010 to 2017 Trzcionkowska, Kasia Vehmeijer, Wouter B.H.J. Kerkhoff, Frank T. Bauer, Noel J.C. Bennebroek, Carlien A.M. Dijk, Peter H. Dijkman, Koen P. van den Dungen, Frank A.M. Eggink, Cathrien A. Feenstra, Robert P.G. Groenendaal, Floris van Heijst, Arno F. van der Hoeven, Mark A.H.B.M. Kornelisse, Rene F. Kraal‐Biezen, Elke Lopriore, Enrico Onland, Wes Renardel de Lavalette, Victor W. van Rijn, Laurentius J. Schuerman, Frank A.B.A. Simonsz, Huibert J. Voskuil‐Kerkhof, Elsbeth S.M. Witlox, Ruben S.G.M. Termote, Jacqueline U.M. Schalij‐Delfos, Nicoline E. Acta Ophthalmol Original Articles PURPOSE: Compare patients treated for Retinopathy of Prematurity (ROP) in two consecutive periods. METHODS: Retrospective inventory of anonymized neonatal and ophthalmological data of all patients treated for ROP from 2010 to 2017 in the Netherlands, subdivided in period (P)1: 1‐1‐2010 to 31‐3‐2013 and P2: 1‐4‐2013 to 31‐12‐2016. Treatment characteristics, adherence to early treatment for ROP (ETROP) criteria, outcome of treatment and changes in neonatal parameters and policy of care were compared. RESULTS: Overall 196 infants were included, 57 infants (113 eyes) in P1 and 139 (275 eyes) in P2, indicating a 2.1‐fold increase in ROP treatment. No differences were found in mean gestational age (GA) (25.9 ± 1.7 versus 26.0 ± 1.7 weeks, p = 0.711), mean birth weight (791 ± 311 versus 764 ± 204 grams, p = 0.967) and other neonatal risk factors for ROP. In P2, the number of premature infants born <25 weeks increased by factor 1.23 and higher oxygen saturation levels were aimed at in most centres. At treatment decision, 59.6% (P1) versus 83.5% (P2) (p = 0.263) infants were classified as Type 1 ROP (ETROP classification). Infants were treated with laser photocoagulation (98 versus 96%) and intravitreal bevacizumab (2 versus 4%). Retreatment was necessary in 10 versus 21 (p = 0.160). Retinal detachment developed in 6 versus 13 infants (p = 0.791) of which 2 versus 6 bilateral (p = 0.599). CONCLUSION: In period 2, the number of infants treated according to the ETROP criteria (Type 1) increased, the number of ROP treatments, retinal detachments and retreatments doubled and the absolute number of retinal detachments increased. Neonatal data did not provide a decisive explanation, although changes in neonatal policy were reported. John Wiley and Sons Inc. 2020-07-23 2021-02 /pmc/articles/PMC7891652/ /pubmed/32701185 http://dx.doi.org/10.1111/aos.14501 Text en © 2020 The Authors. Acta Ophthalmologica published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Trzcionkowska, Kasia
Vehmeijer, Wouter B.H.J.
Kerkhoff, Frank T.
Bauer, Noel J.C.
Bennebroek, Carlien A.M.
Dijk, Peter H.
Dijkman, Koen P.
van den Dungen, Frank A.M.
Eggink, Cathrien A.
Feenstra, Robert P.G.
Groenendaal, Floris
van Heijst, Arno F.
van der Hoeven, Mark A.H.B.M.
Kornelisse, Rene F.
Kraal‐Biezen, Elke
Lopriore, Enrico
Onland, Wes
Renardel de Lavalette, Victor W.
van Rijn, Laurentius J.
Schuerman, Frank A.B.A.
Simonsz, Huibert J.
Voskuil‐Kerkhof, Elsbeth S.M.
Witlox, Ruben S.G.M.
Termote, Jacqueline U.M.
Schalij‐Delfos, Nicoline E.
Increase in treatment of retinopathy of prematurity in the Netherlands from 2010 to 2017
title Increase in treatment of retinopathy of prematurity in the Netherlands from 2010 to 2017
title_full Increase in treatment of retinopathy of prematurity in the Netherlands from 2010 to 2017
title_fullStr Increase in treatment of retinopathy of prematurity in the Netherlands from 2010 to 2017
title_full_unstemmed Increase in treatment of retinopathy of prematurity in the Netherlands from 2010 to 2017
title_short Increase in treatment of retinopathy of prematurity in the Netherlands from 2010 to 2017
title_sort increase in treatment of retinopathy of prematurity in the netherlands from 2010 to 2017
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7891652/
https://www.ncbi.nlm.nih.gov/pubmed/32701185
http://dx.doi.org/10.1111/aos.14501
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