Asymptomatic HyperCKemia: A Diagnostic Trap

Elevated creatine kinase (CK) levels are the most sensitive indicator of muscle injury. Levels >5000 U/L warns physicians to initiate aggressive hydration and prevent renal failure. We present a rare case of asymptomatic hyperCkemia with levels >80 times the upper limit of normal (ULN), refrac...

Descripción completa

Detalles Bibliográficos
Autores principales: Shaikh, Safia, Gonzalez- Zapata, Alan, Mujeeb, Abdul, Rauf, Abdul, Thekkemuriyil,, Dany
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7891676/
https://www.ncbi.nlm.nih.gov/pubmed/33628661
http://dx.doi.org/10.7759/cureus.12791
_version_ 1783652750206173184
author Shaikh, Safia
Gonzalez- Zapata, Alan
Mujeeb, Abdul
Rauf, Abdul
Thekkemuriyil,, Dany
author_facet Shaikh, Safia
Gonzalez- Zapata, Alan
Mujeeb, Abdul
Rauf, Abdul
Thekkemuriyil,, Dany
author_sort Shaikh, Safia
collection PubMed
description Elevated creatine kinase (CK) levels are the most sensitive indicator of muscle injury. Levels >5000 U/L warns physicians to initiate aggressive hydration and prevent renal failure. We present a rare case of asymptomatic hyperCkemia with levels >80 times the upper limit of normal (ULN), refractory to fluid resuscitation. Our patient was found to have elevated macroenzymes- macroCkemia, causing decreased clearance of CK. The objective of this case report is to bring to attention a rare and benign cause of CK elevation which can lead to diagnostic and therapeutic errors.
format Online
Article
Text
id pubmed-7891676
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Cureus
record_format MEDLINE/PubMed
spelling pubmed-78916762021-02-23 Asymptomatic HyperCKemia: A Diagnostic Trap Shaikh, Safia Gonzalez- Zapata, Alan Mujeeb, Abdul Rauf, Abdul Thekkemuriyil,, Dany Cureus Internal Medicine Elevated creatine kinase (CK) levels are the most sensitive indicator of muscle injury. Levels >5000 U/L warns physicians to initiate aggressive hydration and prevent renal failure. We present a rare case of asymptomatic hyperCkemia with levels >80 times the upper limit of normal (ULN), refractory to fluid resuscitation. Our patient was found to have elevated macroenzymes- macroCkemia, causing decreased clearance of CK. The objective of this case report is to bring to attention a rare and benign cause of CK elevation which can lead to diagnostic and therapeutic errors. Cureus 2021-01-19 /pmc/articles/PMC7891676/ /pubmed/33628661 http://dx.doi.org/10.7759/cureus.12791 Text en Copyright © 2021, Shaikh et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Shaikh, Safia
Gonzalez- Zapata, Alan
Mujeeb, Abdul
Rauf, Abdul
Thekkemuriyil,, Dany
Asymptomatic HyperCKemia: A Diagnostic Trap
title Asymptomatic HyperCKemia: A Diagnostic Trap
title_full Asymptomatic HyperCKemia: A Diagnostic Trap
title_fullStr Asymptomatic HyperCKemia: A Diagnostic Trap
title_full_unstemmed Asymptomatic HyperCKemia: A Diagnostic Trap
title_short Asymptomatic HyperCKemia: A Diagnostic Trap
title_sort asymptomatic hyperckemia: a diagnostic trap
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7891676/
https://www.ncbi.nlm.nih.gov/pubmed/33628661
http://dx.doi.org/10.7759/cureus.12791
work_keys_str_mv AT shaikhsafia asymptomatichyperckemiaadiagnostictrap
AT gonzalezzapataalan asymptomatichyperckemiaadiagnostictrap
AT mujeebabdul asymptomatichyperckemiaadiagnostictrap
AT raufabdul asymptomatichyperckemiaadiagnostictrap
AT thekkemuriyildany asymptomatichyperckemiaadiagnostictrap

Ejemplares similares