Shared and distinct roles of Esc2 and Mms21 in suppressing genome rearrangements and regulating intracellular sumoylation

Protein sumoylation, especially when catalyzed by the Mms21 SUMO E3 ligase, plays a major role in suppressing duplication-mediated gross chromosomal rearrangements (dGCRs). How Mms21 targets its substrates in the cell is insufficiently understood. Here, we demonstrate that Esc2, a protein with SUMO-...

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Detalles Bibliográficos
Autores principales: Suhandynata, Raymond T., Gao, Yong-Qi, Zhou, Ann L., Yang, Yusheng, Wang, Pang-Che, Zhou, Huilin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7891725/
https://www.ncbi.nlm.nih.gov/pubmed/33600463
http://dx.doi.org/10.1371/journal.pone.0247132

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7891725/
https://www.ncbi.nlm.nih.gov/pubmed/33600463
http://dx.doi.org/10.1371/journal.pone.0247132

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