Mitochondria-targeted therapeutics, MitoQ and BGP-15, reverse aging-associated meiotic spindle defects in mouse and human oocytes

STUDY QUESTION: Do mitochondria-targeted therapies reverse ageing- and oxidative stress-induced spindle defects in oocytes from mice and humans? SUMMARY ANSWER: Exposure to MitoQ or BGP-15 during IVM protected against spindle and chromosomal defects in mouse oocytes exposed to oxidative stress or de...

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Detalles Bibliográficos
Autores principales: Al-Zubaidi, Usama, Adhikari, Deepak, Cinar, Ozgur, Zhang, Qing-Hua, Yuen, Wai Shan, Murphy, Michael P, Rombauts, Luk, Robker, Rebecca L, Carroll, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7891816/
https://www.ncbi.nlm.nih.gov/pubmed/33367783
http://dx.doi.org/10.1093/humrep/deaa300

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