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Pineal hormone melatonin as an adjuvant treatment for COVID-19 (Review)

The beneficial properties of the pineal hormone, melatonin, as a neuroprotective and cardioprotective agent, have been previously identified. Furthermore, melatonin plays essential roles in biological rhythms resynchronization, sleep initiation/maintenance and metabolic, ocular, rheumatological dise...

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Autores principales: Vlachou, Marilena, Siamidi, Angeliki, Dedeloudi, Aikaterini, Konstantinidou, Sofia K., Papanastasiou, Ioannis P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7891824/
https://www.ncbi.nlm.nih.gov/pubmed/33576451
http://dx.doi.org/10.3892/ijmm.2021.4880
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author Vlachou, Marilena
Siamidi, Angeliki
Dedeloudi, Aikaterini
Konstantinidou, Sofia K.
Papanastasiou, Ioannis P.
author_facet Vlachou, Marilena
Siamidi, Angeliki
Dedeloudi, Aikaterini
Konstantinidou, Sofia K.
Papanastasiou, Ioannis P.
author_sort Vlachou, Marilena
collection PubMed
description The beneficial properties of the pineal hormone, melatonin, as a neuroprotective and cardioprotective agent, have been previously identified. Furthermore, melatonin plays essential roles in biological rhythms resynchronization, sleep initiation/maintenance and metabolic, ocular, rheumatological diseases. In addition to these functions, melatonin is known to exert immunomodulation, anti-inflammatory and anti-oxidative effects. Due to these properties, coupled with its non-toxic nature, melatonin has been suggested to limit viral infections; however, melatonin cannot be classified as a viricidal drug. In addition, the recent increase in the number of clinical trials on melatonin's role, as an adjuvant treatment for COVID-19, has resurged the interest of the scientific community in this hormone. The present short review aimed to improve the understanding of the antiviral/anti-COVID-19 profile of melatonin and the clinical trials that have recently been conducted, with respect to its co-administration in treating individuals with COVID-19.
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spelling pubmed-78918242021-03-16 Pineal hormone melatonin as an adjuvant treatment for COVID-19 (Review) Vlachou, Marilena Siamidi, Angeliki Dedeloudi, Aikaterini Konstantinidou, Sofia K. Papanastasiou, Ioannis P. Int J Mol Med Articles The beneficial properties of the pineal hormone, melatonin, as a neuroprotective and cardioprotective agent, have been previously identified. Furthermore, melatonin plays essential roles in biological rhythms resynchronization, sleep initiation/maintenance and metabolic, ocular, rheumatological diseases. In addition to these functions, melatonin is known to exert immunomodulation, anti-inflammatory and anti-oxidative effects. Due to these properties, coupled with its non-toxic nature, melatonin has been suggested to limit viral infections; however, melatonin cannot be classified as a viricidal drug. In addition, the recent increase in the number of clinical trials on melatonin's role, as an adjuvant treatment for COVID-19, has resurged the interest of the scientific community in this hormone. The present short review aimed to improve the understanding of the antiviral/anti-COVID-19 profile of melatonin and the clinical trials that have recently been conducted, with respect to its co-administration in treating individuals with COVID-19. D.A. Spandidos 2021-04 2021-02-09 /pmc/articles/PMC7891824/ /pubmed/33576451 http://dx.doi.org/10.3892/ijmm.2021.4880 Text en Copyright: © Vlachou et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Vlachou, Marilena
Siamidi, Angeliki
Dedeloudi, Aikaterini
Konstantinidou, Sofia K.
Papanastasiou, Ioannis P.
Pineal hormone melatonin as an adjuvant treatment for COVID-19 (Review)
title Pineal hormone melatonin as an adjuvant treatment for COVID-19 (Review)
title_full Pineal hormone melatonin as an adjuvant treatment for COVID-19 (Review)
title_fullStr Pineal hormone melatonin as an adjuvant treatment for COVID-19 (Review)
title_full_unstemmed Pineal hormone melatonin as an adjuvant treatment for COVID-19 (Review)
title_short Pineal hormone melatonin as an adjuvant treatment for COVID-19 (Review)
title_sort pineal hormone melatonin as an adjuvant treatment for covid-19 (review)
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7891824/
https://www.ncbi.nlm.nih.gov/pubmed/33576451
http://dx.doi.org/10.3892/ijmm.2021.4880
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