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Targeting a Pathogenic Cysteine Mutation: Discovery of a Specific Inhibitor of Y279C SHP2

[Image: see text] An intriguing challenge of drug discovery is targeting pathogenic mutant proteins that differ from their wild-type counterparts by only a single amino acid. In particular, pathogenic cysteine mutations afford promising opportunities for mutant-specific drug discovery, due to the un...

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Detalles Bibliográficos
Autores principales: Kim, Jenny Y., Plaman, Bailey A., Bishop, Anthony C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7891893/
https://www.ncbi.nlm.nih.gov/pubmed/32871078
http://dx.doi.org/10.1021/acs.biochem.0c00471