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Mortality and Attrition Rates within the First Year of Antiretroviral Therapy Initiation among People Living with HIV in Guangxi, China: An Observational Cohort Study

OBJECTIVE: To assess the mortality and attrition rates within the first year of antiretroviral therapy (ART) initiation among people living with human immunodeficiency virus (PLHIV) in rural Guangxi, China. DESIGN: Observational cohort study. Setting. The core treatment indicators and data were coll...

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Autores principales: Zhu, Jinhui, Yousuf, Mohammed Adnan, Yang, Wenmin, Zhu, Qiuying, Shen, Zhiyong, Lan, Guanghua, Chen, Yi, Chen, Huanhuan, Fan, Wensheng, Xing, Hui, Shao, Yiming, Ruan, Yuhua, Li, Liming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892219/
https://www.ncbi.nlm.nih.gov/pubmed/33628803
http://dx.doi.org/10.1155/2021/6657112
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author Zhu, Jinhui
Yousuf, Mohammed Adnan
Yang, Wenmin
Zhu, Qiuying
Shen, Zhiyong
Lan, Guanghua
Chen, Yi
Chen, Huanhuan
Fan, Wensheng
Xing, Hui
Shao, Yiming
Ruan, Yuhua
Li, Liming
author_facet Zhu, Jinhui
Yousuf, Mohammed Adnan
Yang, Wenmin
Zhu, Qiuying
Shen, Zhiyong
Lan, Guanghua
Chen, Yi
Chen, Huanhuan
Fan, Wensheng
Xing, Hui
Shao, Yiming
Ruan, Yuhua
Li, Liming
author_sort Zhu, Jinhui
collection PubMed
description OBJECTIVE: To assess the mortality and attrition rates within the first year of antiretroviral therapy (ART) initiation among people living with human immunodeficiency virus (PLHIV) in rural Guangxi, China. DESIGN: Observational cohort study. Setting. The core treatment indicators and data were collected with standard and essential procedures as per the Free ART Manual guidelines across all the rural health care centers of Guangxi. Participants. 58,115 PLHIV who were under ART were included in the study. Interventions. The data collected included sociodemographic characteristics that consist of age, sex, marital status, route of HIV transmission, CD4 cell count before ART, initial ART regimen, level of ART site, and year of ART initiation. Primary and Secondary Outcome Measures. Mortality and attrition rate following ART initiation. RESULTS: The average mortality rate was 5.94 deaths, and 17.52 attritions per 100 person-years within the first year of ART initiation among PLHIV. The mortality rate was higher among intravenous drug users (Adjusted Hazard Ratio (AHR) 1.27, 95% Confidence Interval (CI) 1.14-1.43), prefecture as a level of ART site (AHR 1.14, 95% CI 1.02-1.28), and county as the level of ART site (AHR 2.12, 95% CI 1.90-2.37). Attrition was higher among intravenous drug users (AHR 1.87, 95% CI 1.75-2.00), the first-line ART containing AZT (AHR 1.09, 95% CI 1.03-1.16), and first-line ART containing LVP/r (AHR 1.34, 95% CI 1.23-1.46). CONCLUSION: The mortality and attrition rates were both at the highest level in the first year of post-ART; continued improvement in the quality of HIV treatment and care is needed.
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spelling pubmed-78922192021-02-23 Mortality and Attrition Rates within the First Year of Antiretroviral Therapy Initiation among People Living with HIV in Guangxi, China: An Observational Cohort Study Zhu, Jinhui Yousuf, Mohammed Adnan Yang, Wenmin Zhu, Qiuying Shen, Zhiyong Lan, Guanghua Chen, Yi Chen, Huanhuan Fan, Wensheng Xing, Hui Shao, Yiming Ruan, Yuhua Li, Liming Biomed Res Int Research Article OBJECTIVE: To assess the mortality and attrition rates within the first year of antiretroviral therapy (ART) initiation among people living with human immunodeficiency virus (PLHIV) in rural Guangxi, China. DESIGN: Observational cohort study. Setting. The core treatment indicators and data were collected with standard and essential procedures as per the Free ART Manual guidelines across all the rural health care centers of Guangxi. Participants. 58,115 PLHIV who were under ART were included in the study. Interventions. The data collected included sociodemographic characteristics that consist of age, sex, marital status, route of HIV transmission, CD4 cell count before ART, initial ART regimen, level of ART site, and year of ART initiation. Primary and Secondary Outcome Measures. Mortality and attrition rate following ART initiation. RESULTS: The average mortality rate was 5.94 deaths, and 17.52 attritions per 100 person-years within the first year of ART initiation among PLHIV. The mortality rate was higher among intravenous drug users (Adjusted Hazard Ratio (AHR) 1.27, 95% Confidence Interval (CI) 1.14-1.43), prefecture as a level of ART site (AHR 1.14, 95% CI 1.02-1.28), and county as the level of ART site (AHR 2.12, 95% CI 1.90-2.37). Attrition was higher among intravenous drug users (AHR 1.87, 95% CI 1.75-2.00), the first-line ART containing AZT (AHR 1.09, 95% CI 1.03-1.16), and first-line ART containing LVP/r (AHR 1.34, 95% CI 1.23-1.46). CONCLUSION: The mortality and attrition rates were both at the highest level in the first year of post-ART; continued improvement in the quality of HIV treatment and care is needed. Hindawi 2021-02-10 /pmc/articles/PMC7892219/ /pubmed/33628803 http://dx.doi.org/10.1155/2021/6657112 Text en Copyright © 2021 Jinhui Zhu et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhu, Jinhui
Yousuf, Mohammed Adnan
Yang, Wenmin
Zhu, Qiuying
Shen, Zhiyong
Lan, Guanghua
Chen, Yi
Chen, Huanhuan
Fan, Wensheng
Xing, Hui
Shao, Yiming
Ruan, Yuhua
Li, Liming
Mortality and Attrition Rates within the First Year of Antiretroviral Therapy Initiation among People Living with HIV in Guangxi, China: An Observational Cohort Study
title Mortality and Attrition Rates within the First Year of Antiretroviral Therapy Initiation among People Living with HIV in Guangxi, China: An Observational Cohort Study
title_full Mortality and Attrition Rates within the First Year of Antiretroviral Therapy Initiation among People Living with HIV in Guangxi, China: An Observational Cohort Study
title_fullStr Mortality and Attrition Rates within the First Year of Antiretroviral Therapy Initiation among People Living with HIV in Guangxi, China: An Observational Cohort Study
title_full_unstemmed Mortality and Attrition Rates within the First Year of Antiretroviral Therapy Initiation among People Living with HIV in Guangxi, China: An Observational Cohort Study
title_short Mortality and Attrition Rates within the First Year of Antiretroviral Therapy Initiation among People Living with HIV in Guangxi, China: An Observational Cohort Study
title_sort mortality and attrition rates within the first year of antiretroviral therapy initiation among people living with hiv in guangxi, china: an observational cohort study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892219/
https://www.ncbi.nlm.nih.gov/pubmed/33628803
http://dx.doi.org/10.1155/2021/6657112
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