Cargando…
Mortality and Attrition Rates within the First Year of Antiretroviral Therapy Initiation among People Living with HIV in Guangxi, China: An Observational Cohort Study
OBJECTIVE: To assess the mortality and attrition rates within the first year of antiretroviral therapy (ART) initiation among people living with human immunodeficiency virus (PLHIV) in rural Guangxi, China. DESIGN: Observational cohort study. Setting. The core treatment indicators and data were coll...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892219/ https://www.ncbi.nlm.nih.gov/pubmed/33628803 http://dx.doi.org/10.1155/2021/6657112 |
_version_ | 1783652800995000320 |
---|---|
author | Zhu, Jinhui Yousuf, Mohammed Adnan Yang, Wenmin Zhu, Qiuying Shen, Zhiyong Lan, Guanghua Chen, Yi Chen, Huanhuan Fan, Wensheng Xing, Hui Shao, Yiming Ruan, Yuhua Li, Liming |
author_facet | Zhu, Jinhui Yousuf, Mohammed Adnan Yang, Wenmin Zhu, Qiuying Shen, Zhiyong Lan, Guanghua Chen, Yi Chen, Huanhuan Fan, Wensheng Xing, Hui Shao, Yiming Ruan, Yuhua Li, Liming |
author_sort | Zhu, Jinhui |
collection | PubMed |
description | OBJECTIVE: To assess the mortality and attrition rates within the first year of antiretroviral therapy (ART) initiation among people living with human immunodeficiency virus (PLHIV) in rural Guangxi, China. DESIGN: Observational cohort study. Setting. The core treatment indicators and data were collected with standard and essential procedures as per the Free ART Manual guidelines across all the rural health care centers of Guangxi. Participants. 58,115 PLHIV who were under ART were included in the study. Interventions. The data collected included sociodemographic characteristics that consist of age, sex, marital status, route of HIV transmission, CD4 cell count before ART, initial ART regimen, level of ART site, and year of ART initiation. Primary and Secondary Outcome Measures. Mortality and attrition rate following ART initiation. RESULTS: The average mortality rate was 5.94 deaths, and 17.52 attritions per 100 person-years within the first year of ART initiation among PLHIV. The mortality rate was higher among intravenous drug users (Adjusted Hazard Ratio (AHR) 1.27, 95% Confidence Interval (CI) 1.14-1.43), prefecture as a level of ART site (AHR 1.14, 95% CI 1.02-1.28), and county as the level of ART site (AHR 2.12, 95% CI 1.90-2.37). Attrition was higher among intravenous drug users (AHR 1.87, 95% CI 1.75-2.00), the first-line ART containing AZT (AHR 1.09, 95% CI 1.03-1.16), and first-line ART containing LVP/r (AHR 1.34, 95% CI 1.23-1.46). CONCLUSION: The mortality and attrition rates were both at the highest level in the first year of post-ART; continued improvement in the quality of HIV treatment and care is needed. |
format | Online Article Text |
id | pubmed-7892219 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-78922192021-02-23 Mortality and Attrition Rates within the First Year of Antiretroviral Therapy Initiation among People Living with HIV in Guangxi, China: An Observational Cohort Study Zhu, Jinhui Yousuf, Mohammed Adnan Yang, Wenmin Zhu, Qiuying Shen, Zhiyong Lan, Guanghua Chen, Yi Chen, Huanhuan Fan, Wensheng Xing, Hui Shao, Yiming Ruan, Yuhua Li, Liming Biomed Res Int Research Article OBJECTIVE: To assess the mortality and attrition rates within the first year of antiretroviral therapy (ART) initiation among people living with human immunodeficiency virus (PLHIV) in rural Guangxi, China. DESIGN: Observational cohort study. Setting. The core treatment indicators and data were collected with standard and essential procedures as per the Free ART Manual guidelines across all the rural health care centers of Guangxi. Participants. 58,115 PLHIV who were under ART were included in the study. Interventions. The data collected included sociodemographic characteristics that consist of age, sex, marital status, route of HIV transmission, CD4 cell count before ART, initial ART regimen, level of ART site, and year of ART initiation. Primary and Secondary Outcome Measures. Mortality and attrition rate following ART initiation. RESULTS: The average mortality rate was 5.94 deaths, and 17.52 attritions per 100 person-years within the first year of ART initiation among PLHIV. The mortality rate was higher among intravenous drug users (Adjusted Hazard Ratio (AHR) 1.27, 95% Confidence Interval (CI) 1.14-1.43), prefecture as a level of ART site (AHR 1.14, 95% CI 1.02-1.28), and county as the level of ART site (AHR 2.12, 95% CI 1.90-2.37). Attrition was higher among intravenous drug users (AHR 1.87, 95% CI 1.75-2.00), the first-line ART containing AZT (AHR 1.09, 95% CI 1.03-1.16), and first-line ART containing LVP/r (AHR 1.34, 95% CI 1.23-1.46). CONCLUSION: The mortality and attrition rates were both at the highest level in the first year of post-ART; continued improvement in the quality of HIV treatment and care is needed. Hindawi 2021-02-10 /pmc/articles/PMC7892219/ /pubmed/33628803 http://dx.doi.org/10.1155/2021/6657112 Text en Copyright © 2021 Jinhui Zhu et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Zhu, Jinhui Yousuf, Mohammed Adnan Yang, Wenmin Zhu, Qiuying Shen, Zhiyong Lan, Guanghua Chen, Yi Chen, Huanhuan Fan, Wensheng Xing, Hui Shao, Yiming Ruan, Yuhua Li, Liming Mortality and Attrition Rates within the First Year of Antiretroviral Therapy Initiation among People Living with HIV in Guangxi, China: An Observational Cohort Study |
title | Mortality and Attrition Rates within the First Year of Antiretroviral Therapy Initiation among People Living with HIV in Guangxi, China: An Observational Cohort Study |
title_full | Mortality and Attrition Rates within the First Year of Antiretroviral Therapy Initiation among People Living with HIV in Guangxi, China: An Observational Cohort Study |
title_fullStr | Mortality and Attrition Rates within the First Year of Antiretroviral Therapy Initiation among People Living with HIV in Guangxi, China: An Observational Cohort Study |
title_full_unstemmed | Mortality and Attrition Rates within the First Year of Antiretroviral Therapy Initiation among People Living with HIV in Guangxi, China: An Observational Cohort Study |
title_short | Mortality and Attrition Rates within the First Year of Antiretroviral Therapy Initiation among People Living with HIV in Guangxi, China: An Observational Cohort Study |
title_sort | mortality and attrition rates within the first year of antiretroviral therapy initiation among people living with hiv in guangxi, china: an observational cohort study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892219/ https://www.ncbi.nlm.nih.gov/pubmed/33628803 http://dx.doi.org/10.1155/2021/6657112 |
work_keys_str_mv | AT zhujinhui mortalityandattritionrateswithinthefirstyearofantiretroviraltherapyinitiationamongpeoplelivingwithhivinguangxichinaanobservationalcohortstudy AT yousufmohammedadnan mortalityandattritionrateswithinthefirstyearofantiretroviraltherapyinitiationamongpeoplelivingwithhivinguangxichinaanobservationalcohortstudy AT yangwenmin mortalityandattritionrateswithinthefirstyearofantiretroviraltherapyinitiationamongpeoplelivingwithhivinguangxichinaanobservationalcohortstudy AT zhuqiuying mortalityandattritionrateswithinthefirstyearofantiretroviraltherapyinitiationamongpeoplelivingwithhivinguangxichinaanobservationalcohortstudy AT shenzhiyong mortalityandattritionrateswithinthefirstyearofantiretroviraltherapyinitiationamongpeoplelivingwithhivinguangxichinaanobservationalcohortstudy AT languanghua mortalityandattritionrateswithinthefirstyearofantiretroviraltherapyinitiationamongpeoplelivingwithhivinguangxichinaanobservationalcohortstudy AT chenyi mortalityandattritionrateswithinthefirstyearofantiretroviraltherapyinitiationamongpeoplelivingwithhivinguangxichinaanobservationalcohortstudy AT chenhuanhuan mortalityandattritionrateswithinthefirstyearofantiretroviraltherapyinitiationamongpeoplelivingwithhivinguangxichinaanobservationalcohortstudy AT fanwensheng mortalityandattritionrateswithinthefirstyearofantiretroviraltherapyinitiationamongpeoplelivingwithhivinguangxichinaanobservationalcohortstudy AT xinghui mortalityandattritionrateswithinthefirstyearofantiretroviraltherapyinitiationamongpeoplelivingwithhivinguangxichinaanobservationalcohortstudy AT shaoyiming mortalityandattritionrateswithinthefirstyearofantiretroviraltherapyinitiationamongpeoplelivingwithhivinguangxichinaanobservationalcohortstudy AT ruanyuhua mortalityandattritionrateswithinthefirstyearofantiretroviraltherapyinitiationamongpeoplelivingwithhivinguangxichinaanobservationalcohortstudy AT liliming mortalityandattritionrateswithinthefirstyearofantiretroviraltherapyinitiationamongpeoplelivingwithhivinguangxichinaanobservationalcohortstudy |