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Comparison of colonoscopy after colonic diverticulitis and positive fecal immunochemical tests for the detection of colorectal neoplasia

Background and study aims  The relationship between acute colonic diverticulitis and colorectal cancer (CRC) is unclear, but colonoscopy is recommended to exclude malignancy. We compared the detection rates for colorectal neoplasia in patients with colonic diverticulitis and asymptomatic patients wh...

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Autores principales: Nakamatsu, Dai, Nishida, Tsutomu, Kuriki, Shinji, Chang, Li-sa, Aochi, Kazuki, Meren, Emi, Sakamoto, Tatsuya, Tomita, Ryo, Higaki, Yu, Osugi, Naoto, Sugimoto, Aya, Takahashi, Kei, Mukai, Kaori, Matsumoto, Kengo, Hayashi, Shiro, Nakajima, Sachiko, Yamamoto, Masashi, Fukui, Koji, Inada, Masami
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Georg Thieme Verlag KG 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892274/
https://www.ncbi.nlm.nih.gov/pubmed/33655030
http://dx.doi.org/10.1055/a-1333-1108
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author Nakamatsu, Dai
Nishida, Tsutomu
Kuriki, Shinji
Chang, Li-sa
Aochi, Kazuki
Meren, Emi
Sakamoto, Tatsuya
Tomita, Ryo
Higaki, Yu
Osugi, Naoto
Sugimoto, Aya
Takahashi, Kei
Mukai, Kaori
Matsumoto, Kengo
Hayashi, Shiro
Nakajima, Sachiko
Yamamoto, Masashi
Fukui, Koji
Inada, Masami
author_facet Nakamatsu, Dai
Nishida, Tsutomu
Kuriki, Shinji
Chang, Li-sa
Aochi, Kazuki
Meren, Emi
Sakamoto, Tatsuya
Tomita, Ryo
Higaki, Yu
Osugi, Naoto
Sugimoto, Aya
Takahashi, Kei
Mukai, Kaori
Matsumoto, Kengo
Hayashi, Shiro
Nakajima, Sachiko
Yamamoto, Masashi
Fukui, Koji
Inada, Masami
author_sort Nakamatsu, Dai
collection PubMed
description Background and study aims  The relationship between acute colonic diverticulitis and colorectal cancer (CRC) is unclear, but colonoscopy is recommended to exclude malignancy. We compared the detection rates for colorectal neoplasia in patients with colonic diverticulitis and asymptomatic patients who had positive fecal immunochemical tests (FITs). Patients and methods  In total, 282 patients with acute colonic diverticulitis were hospitalized in our hospital from February 2011 to December 2019. Of them, 143 patients with diverticulitis and 1819 with positive FITs patients during the same period underwent colonoscopy without a prior colonoscopy within 5 years. We retrospectively compared these patients in terms of the invasive CRC rate, advanced neoplasia detection rate (ANDR), adenoma detection rate (ADR), and polyp detection rate (PDR). Results  Compared to the diverticulitis group, the FIT-positive group had a significantly higher CRC rate (0 vs 2.7 %, P  = 0.0061), ANDR (5.6 vs. 14.0 %, P  = 0.0017), ADR (19.6 vs. 53.2 %, P  < .0001), and PDR (44.1 vs. 91.0 %, P  < .0001). Using 1:1 propensity score matching based on age and sex, we obtained 276 matched patients in both groups. After matching, no difference was found in the CRC rate (0 vs 0.7 %) or ANDR (5.8 vs 7.3 %) between groups, but the ADR and PDR were significantly higher in the FIT-positive group (20.3 vs 43.5 %, P  < .0001; 45.7 % vs 86.2 %, P  < .0001). Conclusion  Patients with acute diverticulitis had lower ADRs and PDRs than patients with positive FITs.
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spelling pubmed-78922742021-03-01 Comparison of colonoscopy after colonic diverticulitis and positive fecal immunochemical tests for the detection of colorectal neoplasia Nakamatsu, Dai Nishida, Tsutomu Kuriki, Shinji Chang, Li-sa Aochi, Kazuki Meren, Emi Sakamoto, Tatsuya Tomita, Ryo Higaki, Yu Osugi, Naoto Sugimoto, Aya Takahashi, Kei Mukai, Kaori Matsumoto, Kengo Hayashi, Shiro Nakajima, Sachiko Yamamoto, Masashi Fukui, Koji Inada, Masami Endosc Int Open Background and study aims  The relationship between acute colonic diverticulitis and colorectal cancer (CRC) is unclear, but colonoscopy is recommended to exclude malignancy. We compared the detection rates for colorectal neoplasia in patients with colonic diverticulitis and asymptomatic patients who had positive fecal immunochemical tests (FITs). Patients and methods  In total, 282 patients with acute colonic diverticulitis were hospitalized in our hospital from February 2011 to December 2019. Of them, 143 patients with diverticulitis and 1819 with positive FITs patients during the same period underwent colonoscopy without a prior colonoscopy within 5 years. We retrospectively compared these patients in terms of the invasive CRC rate, advanced neoplasia detection rate (ANDR), adenoma detection rate (ADR), and polyp detection rate (PDR). Results  Compared to the diverticulitis group, the FIT-positive group had a significantly higher CRC rate (0 vs 2.7 %, P  = 0.0061), ANDR (5.6 vs. 14.0 %, P  = 0.0017), ADR (19.6 vs. 53.2 %, P  < .0001), and PDR (44.1 vs. 91.0 %, P  < .0001). Using 1:1 propensity score matching based on age and sex, we obtained 276 matched patients in both groups. After matching, no difference was found in the CRC rate (0 vs 0.7 %) or ANDR (5.8 vs 7.3 %) between groups, but the ADR and PDR were significantly higher in the FIT-positive group (20.3 vs 43.5 %, P  < .0001; 45.7 % vs 86.2 %, P  < .0001). Conclusion  Patients with acute diverticulitis had lower ADRs and PDRs than patients with positive FITs. Georg Thieme Verlag KG 2021-03 2021-02-18 /pmc/articles/PMC7892274/ /pubmed/33655030 http://dx.doi.org/10.1055/a-1333-1108 Text en The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/) https://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
spellingShingle Nakamatsu, Dai
Nishida, Tsutomu
Kuriki, Shinji
Chang, Li-sa
Aochi, Kazuki
Meren, Emi
Sakamoto, Tatsuya
Tomita, Ryo
Higaki, Yu
Osugi, Naoto
Sugimoto, Aya
Takahashi, Kei
Mukai, Kaori
Matsumoto, Kengo
Hayashi, Shiro
Nakajima, Sachiko
Yamamoto, Masashi
Fukui, Koji
Inada, Masami
Comparison of colonoscopy after colonic diverticulitis and positive fecal immunochemical tests for the detection of colorectal neoplasia
title Comparison of colonoscopy after colonic diverticulitis and positive fecal immunochemical tests for the detection of colorectal neoplasia
title_full Comparison of colonoscopy after colonic diverticulitis and positive fecal immunochemical tests for the detection of colorectal neoplasia
title_fullStr Comparison of colonoscopy after colonic diverticulitis and positive fecal immunochemical tests for the detection of colorectal neoplasia
title_full_unstemmed Comparison of colonoscopy after colonic diverticulitis and positive fecal immunochemical tests for the detection of colorectal neoplasia
title_short Comparison of colonoscopy after colonic diverticulitis and positive fecal immunochemical tests for the detection of colorectal neoplasia
title_sort comparison of colonoscopy after colonic diverticulitis and positive fecal immunochemical tests for the detection of colorectal neoplasia
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892274/
https://www.ncbi.nlm.nih.gov/pubmed/33655030
http://dx.doi.org/10.1055/a-1333-1108
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