Comparative analysis of the AIB1 interactome in breast cancer reveals MTA2 as a repressive partner which silences E-Cadherin to promote EMT and associates with a pro-metastatic phenotype

Steroid regulated cancer cells use nuclear receptors and associated regulatory proteins to orchestrate transcriptional networks to drive disease progression. In primary breast cancer, the coactivator AIB1 promotes estrogen receptor (ER) transcriptional activity to enhance cell proliferation. The fun...

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Detalles Bibliográficos
Autores principales: Varešlija, Damir, Ward, Elspeth, Purcell, Siobhan P., Cosgrove, Nicola S., Cocchiglia, Sinéad, O’Halloran, Philip J., Charmsaz, Sara, Bane, Fiona T., Brett, Francesca M., Farrell, Michael, Cryan, Jane, Beausang, Alan, Hudson, Lance, Turnbul, Arran K., Dixon, J. Michael, Hill, Arnold D. K., Priedigkeit, Nolan, Oesterreich, Steffi, Lee, Adrian V., Sims, Andrew H., Redmond, Aisling M., Carroll, Jason S., Young, Leonie S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892341/
https://www.ncbi.nlm.nih.gov/pubmed/33420368
http://dx.doi.org/10.1038/s41388-020-01606-3

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