Several FDA-Approved Drugs Effectively Inhibit SARS-CoV-2 Infection in vitro

To identify drugs that are potentially used for the treatment of COVID-19, the potency of 1403 FDA-approved drugs were evaluated using a robust pseudovirus assay and the candidates were further confirmed by authentic SARS-CoV-2 assay. Four compounds, Clomiphene (citrate), Vortioxetine, Vortioxetine...

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Detalles Bibliográficos
Autores principales: Xiong, Hua-Long, Cao, Jia-Li, Shen, Chen-Guang, Ma, Jian, Qiao, Xiao-Yang, Shi, Tian-Shu, Ge, Sheng-Xiang, Ye, Hui-Ming, Zhang, Jun, Yuan, Quan, Zhang, Tian-Ying, Xia, Ning-Shao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892437/
https://www.ncbi.nlm.nih.gov/pubmed/33613282
http://dx.doi.org/10.3389/fphar.2020.609592
Descripción
Sumario:To identify drugs that are potentially used for the treatment of COVID-19, the potency of 1403 FDA-approved drugs were evaluated using a robust pseudovirus assay and the candidates were further confirmed by authentic SARS-CoV-2 assay. Four compounds, Clomiphene (citrate), Vortioxetine, Vortioxetine (hydrobromide) and Asenapine (hydrochloride), showed potent inhibitory effects in both pseudovirus and authentic virus assay. The combination of Clomiphene (citrate), Vortioxetine and Asenapine (hydrochloride) is much more potent than used alone, with IC50 of 0.34 μM.

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