Several FDA-Approved Drugs Effectively Inhibit SARS-CoV-2 Infection in vitro

To identify drugs that are potentially used for the treatment of COVID-19, the potency of 1403 FDA-approved drugs were evaluated using a robust pseudovirus assay and the candidates were further confirmed by authentic SARS-CoV-2 assay. Four compounds, Clomiphene (citrate), Vortioxetine, Vortioxetine...

Descripción completa

Detalles Bibliográficos
Autores principales: Xiong, Hua-Long, Cao, Jia-Li, Shen, Chen-Guang, Ma, Jian, Qiao, Xiao-Yang, Shi, Tian-Shu, Ge, Sheng-Xiang, Ye, Hui-Ming, Zhang, Jun, Yuan, Quan, Zhang, Tian-Ying, Xia, Ning-Shao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892437/
https://www.ncbi.nlm.nih.gov/pubmed/33613282
http://dx.doi.org/10.3389/fphar.2020.609592
_version_ 1783652843944673280
author Xiong, Hua-Long
Cao, Jia-Li
Shen, Chen-Guang
Ma, Jian
Qiao, Xiao-Yang
Shi, Tian-Shu
Ge, Sheng-Xiang
Ye, Hui-Ming
Zhang, Jun
Yuan, Quan
Zhang, Tian-Ying
Xia, Ning-Shao
author_facet Xiong, Hua-Long
Cao, Jia-Li
Shen, Chen-Guang
Ma, Jian
Qiao, Xiao-Yang
Shi, Tian-Shu
Ge, Sheng-Xiang
Ye, Hui-Ming
Zhang, Jun
Yuan, Quan
Zhang, Tian-Ying
Xia, Ning-Shao
author_sort Xiong, Hua-Long
collection PubMed
description To identify drugs that are potentially used for the treatment of COVID-19, the potency of 1403 FDA-approved drugs were evaluated using a robust pseudovirus assay and the candidates were further confirmed by authentic SARS-CoV-2 assay. Four compounds, Clomiphene (citrate), Vortioxetine, Vortioxetine (hydrobromide) and Asenapine (hydrochloride), showed potent inhibitory effects in both pseudovirus and authentic virus assay. The combination of Clomiphene (citrate), Vortioxetine and Asenapine (hydrochloride) is much more potent than used alone, with IC50 of 0.34 μM.
format Online
Article
Text
id pubmed-7892437
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-78924372021-02-20 Several FDA-Approved Drugs Effectively Inhibit SARS-CoV-2 Infection in vitro Xiong, Hua-Long Cao, Jia-Li Shen, Chen-Guang Ma, Jian Qiao, Xiao-Yang Shi, Tian-Shu Ge, Sheng-Xiang Ye, Hui-Ming Zhang, Jun Yuan, Quan Zhang, Tian-Ying Xia, Ning-Shao Front Pharmacol Pharmacology To identify drugs that are potentially used for the treatment of COVID-19, the potency of 1403 FDA-approved drugs were evaluated using a robust pseudovirus assay and the candidates were further confirmed by authentic SARS-CoV-2 assay. Four compounds, Clomiphene (citrate), Vortioxetine, Vortioxetine (hydrobromide) and Asenapine (hydrochloride), showed potent inhibitory effects in both pseudovirus and authentic virus assay. The combination of Clomiphene (citrate), Vortioxetine and Asenapine (hydrochloride) is much more potent than used alone, with IC50 of 0.34 μM. Frontiers Media S.A. 2021-02-05 /pmc/articles/PMC7892437/ /pubmed/33613282 http://dx.doi.org/10.3389/fphar.2020.609592 Text en Copyright © 2021 Xiong, Cao, Shen, Ma, Qiao, Shi, Ge, Ye, Zhang, Yuan, Zhang and Xia. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Xiong, Hua-Long
Cao, Jia-Li
Shen, Chen-Guang
Ma, Jian
Qiao, Xiao-Yang
Shi, Tian-Shu
Ge, Sheng-Xiang
Ye, Hui-Ming
Zhang, Jun
Yuan, Quan
Zhang, Tian-Ying
Xia, Ning-Shao
Several FDA-Approved Drugs Effectively Inhibit SARS-CoV-2 Infection in vitro
title Several FDA-Approved Drugs Effectively Inhibit SARS-CoV-2 Infection in vitro
title_full Several FDA-Approved Drugs Effectively Inhibit SARS-CoV-2 Infection in vitro
title_fullStr Several FDA-Approved Drugs Effectively Inhibit SARS-CoV-2 Infection in vitro
title_full_unstemmed Several FDA-Approved Drugs Effectively Inhibit SARS-CoV-2 Infection in vitro
title_short Several FDA-Approved Drugs Effectively Inhibit SARS-CoV-2 Infection in vitro
title_sort several fda-approved drugs effectively inhibit sars-cov-2 infection in vitro
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892437/
https://www.ncbi.nlm.nih.gov/pubmed/33613282
http://dx.doi.org/10.3389/fphar.2020.609592
work_keys_str_mv AT xionghualong severalfdaapproveddrugseffectivelyinhibitsarscov2infectioninvitro
AT caojiali severalfdaapproveddrugseffectivelyinhibitsarscov2infectioninvitro
AT shenchenguang severalfdaapproveddrugseffectivelyinhibitsarscov2infectioninvitro
AT majian severalfdaapproveddrugseffectivelyinhibitsarscov2infectioninvitro
AT qiaoxiaoyang severalfdaapproveddrugseffectivelyinhibitsarscov2infectioninvitro
AT shitianshu severalfdaapproveddrugseffectivelyinhibitsarscov2infectioninvitro
AT geshengxiang severalfdaapproveddrugseffectivelyinhibitsarscov2infectioninvitro
AT yehuiming severalfdaapproveddrugseffectivelyinhibitsarscov2infectioninvitro
AT zhangjun severalfdaapproveddrugseffectivelyinhibitsarscov2infectioninvitro
AT yuanquan severalfdaapproveddrugseffectivelyinhibitsarscov2infectioninvitro
AT zhangtianying severalfdaapproveddrugseffectivelyinhibitsarscov2infectioninvitro
AT xianingshao severalfdaapproveddrugseffectivelyinhibitsarscov2infectioninvitro

Ejemplares similares