A Review of Newly Diagnosed Glioblastoma

Glioblastoma is an aggressive and inevitably recurrent primary intra-axial brain tumor with a dismal prognosis. The current mainstay of treatment involves maximally safe surgical resection followed by radiotherapy over a 6-week period with concomitant temozolomide chemotherapy followed by temozolomi...

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Autores principales: Oronsky, Bryan, Reid, Tony R., Oronsky, Arnold, Sandhu, Navjot, Knox, Susan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892469/
https://www.ncbi.nlm.nih.gov/pubmed/33614476
http://dx.doi.org/10.3389/fonc.2020.574012
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author Oronsky, Bryan
Reid, Tony R.
Oronsky, Arnold
Sandhu, Navjot
Knox, Susan J.
author_facet Oronsky, Bryan
Reid, Tony R.
Oronsky, Arnold
Sandhu, Navjot
Knox, Susan J.
author_sort Oronsky, Bryan
collection PubMed
description Glioblastoma is an aggressive and inevitably recurrent primary intra-axial brain tumor with a dismal prognosis. The current mainstay of treatment involves maximally safe surgical resection followed by radiotherapy over a 6-week period with concomitant temozolomide chemotherapy followed by temozolomide maintenance. This review provides a summary of the epidemiological, clinical, histologic and genetic characteristics of newly diagnosed disease as well as the current standard of care and potential future therapeutic prospects.
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spelling pubmed-78924692021-02-20 A Review of Newly Diagnosed Glioblastoma Oronsky, Bryan Reid, Tony R. Oronsky, Arnold Sandhu, Navjot Knox, Susan J. Front Oncol Oncology Glioblastoma is an aggressive and inevitably recurrent primary intra-axial brain tumor with a dismal prognosis. The current mainstay of treatment involves maximally safe surgical resection followed by radiotherapy over a 6-week period with concomitant temozolomide chemotherapy followed by temozolomide maintenance. This review provides a summary of the epidemiological, clinical, histologic and genetic characteristics of newly diagnosed disease as well as the current standard of care and potential future therapeutic prospects. Frontiers Media S.A. 2021-02-05 /pmc/articles/PMC7892469/ /pubmed/33614476 http://dx.doi.org/10.3389/fonc.2020.574012 Text en Copyright © 2021 Oronsky, Reid, Oronsky, Sandhu and Knox http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Oronsky, Bryan
Reid, Tony R.
Oronsky, Arnold
Sandhu, Navjot
Knox, Susan J.
A Review of Newly Diagnosed Glioblastoma
title A Review of Newly Diagnosed Glioblastoma
title_full A Review of Newly Diagnosed Glioblastoma
title_fullStr A Review of Newly Diagnosed Glioblastoma
title_full_unstemmed A Review of Newly Diagnosed Glioblastoma
title_short A Review of Newly Diagnosed Glioblastoma
title_sort review of newly diagnosed glioblastoma
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892469/
https://www.ncbi.nlm.nih.gov/pubmed/33614476
http://dx.doi.org/10.3389/fonc.2020.574012
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