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Association between neutrophil–lymphocyte ratio change during living donor liver transplantation and graft survival

Preoperative neutrophil–lymphocyte ratio (NLR), has shown a predictive value in living donor liver transplantation (LDLT). However, the change in the NLR during LDLT has not been fully investigated. We aimed to compare graft survival between the NLR increase and decrease during LDLT. From June 1997...

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Autores principales: Park, Jungchan, Lee, Seung-Hwa, Gwak, Mi Sook, Ko, Justin Sangwook, Han, Sangbin, Choi, Gyu-Seong, Joh, Jae Won, Kim, Jongman, Kim, Gaab Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892541/
https://www.ncbi.nlm.nih.gov/pubmed/33603124
http://dx.doi.org/10.1038/s41598-021-83814-9
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author Park, Jungchan
Lee, Seung-Hwa
Gwak, Mi Sook
Ko, Justin Sangwook
Han, Sangbin
Choi, Gyu-Seong
Joh, Jae Won
Kim, Jongman
Kim, Gaab Soo
author_facet Park, Jungchan
Lee, Seung-Hwa
Gwak, Mi Sook
Ko, Justin Sangwook
Han, Sangbin
Choi, Gyu-Seong
Joh, Jae Won
Kim, Jongman
Kim, Gaab Soo
author_sort Park, Jungchan
collection PubMed
description Preoperative neutrophil–lymphocyte ratio (NLR), has shown a predictive value in living donor liver transplantation (LDLT). However, the change in the NLR during LDLT has not been fully investigated. We aimed to compare graft survival between the NLR increase and decrease during LDLT. From June 1997 to April 2019, we identified 1292 adult LDLT recipients with intraoperative NLR change. The recipients were divided according to NLR change: 103 (8.0%) in the decrease group and 1189 (92.0%) in the increase group. The primary outcome was graft failure in the first year. In addition, variables associated with NLR change during LDLT were evaluated. During 1-year follow-up, graft failure was significantly higher in the decrease group (22.3% vs. 9.1%; hazard ratio 1.87; 95% confidence interval 1.10–3.18; p = 0.02), but postoperative complications did not differ between two groups. This finding was consistent for the overall follow-up. Variables associated with NLR decrease included preoperative NLR > 4, model for end-stage liver disease score, intraoperative inotropic infusion and red blood cell transfusion, and operative duration. The least absolute shrinkage and selection operator model yielded similar results. NLR decrease during LDLT appeared to be independently associated with graft survival. Further studies are needed to confirm our findings.
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spelling pubmed-78925412021-02-22 Association between neutrophil–lymphocyte ratio change during living donor liver transplantation and graft survival Park, Jungchan Lee, Seung-Hwa Gwak, Mi Sook Ko, Justin Sangwook Han, Sangbin Choi, Gyu-Seong Joh, Jae Won Kim, Jongman Kim, Gaab Soo Sci Rep Article Preoperative neutrophil–lymphocyte ratio (NLR), has shown a predictive value in living donor liver transplantation (LDLT). However, the change in the NLR during LDLT has not been fully investigated. We aimed to compare graft survival between the NLR increase and decrease during LDLT. From June 1997 to April 2019, we identified 1292 adult LDLT recipients with intraoperative NLR change. The recipients were divided according to NLR change: 103 (8.0%) in the decrease group and 1189 (92.0%) in the increase group. The primary outcome was graft failure in the first year. In addition, variables associated with NLR change during LDLT were evaluated. During 1-year follow-up, graft failure was significantly higher in the decrease group (22.3% vs. 9.1%; hazard ratio 1.87; 95% confidence interval 1.10–3.18; p = 0.02), but postoperative complications did not differ between two groups. This finding was consistent for the overall follow-up. Variables associated with NLR decrease included preoperative NLR > 4, model for end-stage liver disease score, intraoperative inotropic infusion and red blood cell transfusion, and operative duration. The least absolute shrinkage and selection operator model yielded similar results. NLR decrease during LDLT appeared to be independently associated with graft survival. Further studies are needed to confirm our findings. Nature Publishing Group UK 2021-02-18 /pmc/articles/PMC7892541/ /pubmed/33603124 http://dx.doi.org/10.1038/s41598-021-83814-9 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Park, Jungchan
Lee, Seung-Hwa
Gwak, Mi Sook
Ko, Justin Sangwook
Han, Sangbin
Choi, Gyu-Seong
Joh, Jae Won
Kim, Jongman
Kim, Gaab Soo
Association between neutrophil–lymphocyte ratio change during living donor liver transplantation and graft survival
title Association between neutrophil–lymphocyte ratio change during living donor liver transplantation and graft survival
title_full Association between neutrophil–lymphocyte ratio change during living donor liver transplantation and graft survival
title_fullStr Association between neutrophil–lymphocyte ratio change during living donor liver transplantation and graft survival
title_full_unstemmed Association between neutrophil–lymphocyte ratio change during living donor liver transplantation and graft survival
title_short Association between neutrophil–lymphocyte ratio change during living donor liver transplantation and graft survival
title_sort association between neutrophil–lymphocyte ratio change during living donor liver transplantation and graft survival
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892541/
https://www.ncbi.nlm.nih.gov/pubmed/33603124
http://dx.doi.org/10.1038/s41598-021-83814-9
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