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The incidence of myocardial infarction and stroke in head and neck cancer patients

Various treatment modalities are used for head and neck cancer (HNC). This study analyzed the incidence and risks of myocardial infarction (MI) and stroke by cancer site and treatment modality in 22,737 patients newly diagnosed with HNC registered in the Korean National Health Insurance Service data...

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Autores principales: Kwon, Hyun-Keun, Han, Kyung-Do, Cheon, Yong-Il, Shin, Sung-Chan, Lee, Minhyung, Sung, Eui-Suk, Lee, Jin-Choon, Lee, Byung-Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892553/
https://www.ncbi.nlm.nih.gov/pubmed/33603026
http://dx.doi.org/10.1038/s41598-021-83665-4
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author Kwon, Hyun-Keun
Han, Kyung-Do
Cheon, Yong-Il
Shin, Sung-Chan
Lee, Minhyung
Sung, Eui-Suk
Lee, Jin-Choon
Lee, Byung-Joo
author_facet Kwon, Hyun-Keun
Han, Kyung-Do
Cheon, Yong-Il
Shin, Sung-Chan
Lee, Minhyung
Sung, Eui-Suk
Lee, Jin-Choon
Lee, Byung-Joo
author_sort Kwon, Hyun-Keun
collection PubMed
description Various treatment modalities are used for head and neck cancer (HNC). This study analyzed the incidence and risks of myocardial infarction (MI) and stroke by cancer site and treatment modality in 22,737 patients newly diagnosed with HNC registered in the Korean National Health Insurance Service database in 2007–2013. An additional 68,211 patients without HNC, stroke, or MI were identified as the control group. The risks for MI (hazard ratio [HR] = 1.38, 95% confidence interval [CI] 1.24–1.53), stroke (HR = 1.48, 95% CI 1.37–1.60), and mortality (HR = 5.30, 95% CI 5.14–5.47) were significantly higher in the HNC group. Analysis by cancer site showed the risk of MI and mortality was highest in hypopharynx cancer, while the risk of stroke was highest in nasopharynx and paranasal sinus cancer. Analysis by treatment modality showed the highest risks for MI (HR = 1.88, 95% CI 1.31–2.69) and mortality (HR = 2.95, 95% CI 2.75–3.17) in HNC patients receiving chemotherapy (CT) alone, while HNC patients receiving CT with surgery had the highest risk for stroke (HR = 1.81, 95% CI 1.14–2.88). Careful attention to MI and stroke risks in HNC patients is suggested, especially those who received both CT and radiotherapy.
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spelling pubmed-78925532021-02-22 The incidence of myocardial infarction and stroke in head and neck cancer patients Kwon, Hyun-Keun Han, Kyung-Do Cheon, Yong-Il Shin, Sung-Chan Lee, Minhyung Sung, Eui-Suk Lee, Jin-Choon Lee, Byung-Joo Sci Rep Article Various treatment modalities are used for head and neck cancer (HNC). This study analyzed the incidence and risks of myocardial infarction (MI) and stroke by cancer site and treatment modality in 22,737 patients newly diagnosed with HNC registered in the Korean National Health Insurance Service database in 2007–2013. An additional 68,211 patients without HNC, stroke, or MI were identified as the control group. The risks for MI (hazard ratio [HR] = 1.38, 95% confidence interval [CI] 1.24–1.53), stroke (HR = 1.48, 95% CI 1.37–1.60), and mortality (HR = 5.30, 95% CI 5.14–5.47) were significantly higher in the HNC group. Analysis by cancer site showed the risk of MI and mortality was highest in hypopharynx cancer, while the risk of stroke was highest in nasopharynx and paranasal sinus cancer. Analysis by treatment modality showed the highest risks for MI (HR = 1.88, 95% CI 1.31–2.69) and mortality (HR = 2.95, 95% CI 2.75–3.17) in HNC patients receiving chemotherapy (CT) alone, while HNC patients receiving CT with surgery had the highest risk for stroke (HR = 1.81, 95% CI 1.14–2.88). Careful attention to MI and stroke risks in HNC patients is suggested, especially those who received both CT and radiotherapy. Nature Publishing Group UK 2021-02-18 /pmc/articles/PMC7892553/ /pubmed/33603026 http://dx.doi.org/10.1038/s41598-021-83665-4 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Kwon, Hyun-Keun
Han, Kyung-Do
Cheon, Yong-Il
Shin, Sung-Chan
Lee, Minhyung
Sung, Eui-Suk
Lee, Jin-Choon
Lee, Byung-Joo
The incidence of myocardial infarction and stroke in head and neck cancer patients
title The incidence of myocardial infarction and stroke in head and neck cancer patients
title_full The incidence of myocardial infarction and stroke in head and neck cancer patients
title_fullStr The incidence of myocardial infarction and stroke in head and neck cancer patients
title_full_unstemmed The incidence of myocardial infarction and stroke in head and neck cancer patients
title_short The incidence of myocardial infarction and stroke in head and neck cancer patients
title_sort incidence of myocardial infarction and stroke in head and neck cancer patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892553/
https://www.ncbi.nlm.nih.gov/pubmed/33603026
http://dx.doi.org/10.1038/s41598-021-83665-4
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