Targeting Lactate Metabolism by Inhibiting MCT1 or MCT4 Impairs Leukemic Cell Proliferation, Induces Two Different Related Death-Pathways and Increases Chemotherapeutic Sensitivity of Acute Myeloid Leukemia Cells

Metabolism in acute myeloid leukemia (AML) cells is dependent primarily on oxidative phosphorylation. However, in order to sustain their high proliferation rate and metabolic demand, leukemic blasts use a number of metabolic strategies, including glycolytic metabolism. Understanding whether monocarb...

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Detalles Bibliográficos
Autores principales: Saulle, Ernestina, Spinello, Isabella, Quaranta, Maria Teresa, Pasquini, Luca, Pelosi, Elvira, Iorio, Egidio, Castelli, Germana, Chirico, Mattea, Pisanu, Maria Elena, Ottone, Tiziana, Voso, Maria Teresa, Testa, Ugo, Labbaye, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892602/
https://www.ncbi.nlm.nih.gov/pubmed/33614502
http://dx.doi.org/10.3389/fonc.2020.621458

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