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Sexual Regional Dimorphism of Post-Adolescent and Middle Age Brain Maturation. A Multi-center 3T MRI Study
Sex-related differences are tied into neurodevelopmental and lifespan processes, beginning early in the perinatal and developmental phases and continue into adulthood. The present study was designed to investigate sexual dimorphism of changes in gray matter (GM) volume in post-adolescence, with a fo...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892767/ https://www.ncbi.nlm.nih.gov/pubmed/33613268 http://dx.doi.org/10.3389/fnagi.2021.622054 |
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author | Delvecchio, Giuseppe Maggioni, Eleonora Pigoni, Alessandro Crespo-Facorro, B. Nenadić, Igor Benedetti, Francesco Gaser, Christian Sauer, Heinrich Roiz-Santiañez, Roberto Poletti, Sara Rossetti, Maria G. Bellani, Marcella Perlini, Cinzia Ruggeri, Mirella Diwadkar, Vaibhav A. Brambilla, Paolo |
author_facet | Delvecchio, Giuseppe Maggioni, Eleonora Pigoni, Alessandro Crespo-Facorro, B. Nenadić, Igor Benedetti, Francesco Gaser, Christian Sauer, Heinrich Roiz-Santiañez, Roberto Poletti, Sara Rossetti, Maria G. Bellani, Marcella Perlini, Cinzia Ruggeri, Mirella Diwadkar, Vaibhav A. Brambilla, Paolo |
author_sort | Delvecchio, Giuseppe |
collection | PubMed |
description | Sex-related differences are tied into neurodevelopmental and lifespan processes, beginning early in the perinatal and developmental phases and continue into adulthood. The present study was designed to investigate sexual dimorphism of changes in gray matter (GM) volume in post-adolescence, with a focus on early and middle-adulthood using a structural magnetic resonance imaging (MRI) dataset of healthy controls from the European Network on Psychosis, Affective disorders and Cognitive Trajectory (ENPACT). Three hundred and seventy three subjects underwent a 3.0 T MRI session across four European Centers. Age by sex effects on GM volumes were investigated using voxel-based morphometry (VBM) and the Automated Anatomical Labeling atlas regions (ROI). Females and males showed overlapping and non-overlapping patterns of GM volume changes during aging. Overlapping age-related changes emerged in bilateral frontal and temporal cortices, insula and thalamus. Both VBM and ROI analyses revealed non-overlapping changes in multiple regions, including cerebellum and vermis, bilateral mid frontal, mid occipital cortices, left inferior temporal and precentral gyri. These findings highlight the importance of accounting for sex differences in cross-sectional analyses, not only in the study of normative changes, but particularly in the context of psychiatric and neurologic disorders, wherein sex effects may be confounded with disease-related changes. |
format | Online Article Text |
id | pubmed-7892767 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78927672021-02-20 Sexual Regional Dimorphism of Post-Adolescent and Middle Age Brain Maturation. A Multi-center 3T MRI Study Delvecchio, Giuseppe Maggioni, Eleonora Pigoni, Alessandro Crespo-Facorro, B. Nenadić, Igor Benedetti, Francesco Gaser, Christian Sauer, Heinrich Roiz-Santiañez, Roberto Poletti, Sara Rossetti, Maria G. Bellani, Marcella Perlini, Cinzia Ruggeri, Mirella Diwadkar, Vaibhav A. Brambilla, Paolo Front Aging Neurosci Neuroscience Sex-related differences are tied into neurodevelopmental and lifespan processes, beginning early in the perinatal and developmental phases and continue into adulthood. The present study was designed to investigate sexual dimorphism of changes in gray matter (GM) volume in post-adolescence, with a focus on early and middle-adulthood using a structural magnetic resonance imaging (MRI) dataset of healthy controls from the European Network on Psychosis, Affective disorders and Cognitive Trajectory (ENPACT). Three hundred and seventy three subjects underwent a 3.0 T MRI session across four European Centers. Age by sex effects on GM volumes were investigated using voxel-based morphometry (VBM) and the Automated Anatomical Labeling atlas regions (ROI). Females and males showed overlapping and non-overlapping patterns of GM volume changes during aging. Overlapping age-related changes emerged in bilateral frontal and temporal cortices, insula and thalamus. Both VBM and ROI analyses revealed non-overlapping changes in multiple regions, including cerebellum and vermis, bilateral mid frontal, mid occipital cortices, left inferior temporal and precentral gyri. These findings highlight the importance of accounting for sex differences in cross-sectional analyses, not only in the study of normative changes, but particularly in the context of psychiatric and neurologic disorders, wherein sex effects may be confounded with disease-related changes. Frontiers Media S.A. 2021-02-05 /pmc/articles/PMC7892767/ /pubmed/33613268 http://dx.doi.org/10.3389/fnagi.2021.622054 Text en Copyright © 2021 Delvecchio, Maggioni, Pigoni, Crespo-Facorro, Nenadić, Benedetti, Gaser, Sauer, Roiz-Santiañez, Poletti, Rossetti, Bellani, Perlini, Ruggeri, Diwadkar and Brambilla. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Delvecchio, Giuseppe Maggioni, Eleonora Pigoni, Alessandro Crespo-Facorro, B. Nenadić, Igor Benedetti, Francesco Gaser, Christian Sauer, Heinrich Roiz-Santiañez, Roberto Poletti, Sara Rossetti, Maria G. Bellani, Marcella Perlini, Cinzia Ruggeri, Mirella Diwadkar, Vaibhav A. Brambilla, Paolo Sexual Regional Dimorphism of Post-Adolescent and Middle Age Brain Maturation. A Multi-center 3T MRI Study |
title | Sexual Regional Dimorphism of Post-Adolescent and Middle Age Brain Maturation. A Multi-center 3T MRI Study |
title_full | Sexual Regional Dimorphism of Post-Adolescent and Middle Age Brain Maturation. A Multi-center 3T MRI Study |
title_fullStr | Sexual Regional Dimorphism of Post-Adolescent and Middle Age Brain Maturation. A Multi-center 3T MRI Study |
title_full_unstemmed | Sexual Regional Dimorphism of Post-Adolescent and Middle Age Brain Maturation. A Multi-center 3T MRI Study |
title_short | Sexual Regional Dimorphism of Post-Adolescent and Middle Age Brain Maturation. A Multi-center 3T MRI Study |
title_sort | sexual regional dimorphism of post-adolescent and middle age brain maturation. a multi-center 3t mri study |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892767/ https://www.ncbi.nlm.nih.gov/pubmed/33613268 http://dx.doi.org/10.3389/fnagi.2021.622054 |
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