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Dietary supplementation of silver-silica nanoparticles promotes histological, immunological, ultrastructural, and performance parameters of broiler chickens

Silver nanoparticles (AgNPs) have been used as a promising alternative to antibiotics in poultry feed. In this study, silver-doped silica nanoparticles (SiO(2)@AgNPs) were prepared in powder form, using starch, via the chemical reduction method and sol–gel technique followed by full characterization...

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Autores principales: Dosoky, Waleed M., Fouda, Moustafa M. G., Alwan, Ali B., Abdelsalam, Nader R., Taha, Ayman E., Ghareeb, Rehab Y., El-Aassar, M. R., Khafaga, Asmaa F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892842/
https://www.ncbi.nlm.nih.gov/pubmed/33603060
http://dx.doi.org/10.1038/s41598-021-83753-5
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author Dosoky, Waleed M.
Fouda, Moustafa M. G.
Alwan, Ali B.
Abdelsalam, Nader R.
Taha, Ayman E.
Ghareeb, Rehab Y.
El-Aassar, M. R.
Khafaga, Asmaa F.
author_facet Dosoky, Waleed M.
Fouda, Moustafa M. G.
Alwan, Ali B.
Abdelsalam, Nader R.
Taha, Ayman E.
Ghareeb, Rehab Y.
El-Aassar, M. R.
Khafaga, Asmaa F.
author_sort Dosoky, Waleed M.
collection PubMed
description Silver nanoparticles (AgNPs) have been used as a promising alternative to antibiotics in poultry feed. In this study, silver-doped silica nanoparticles (SiO(2)@AgNPs) were prepared in powder form, using starch, via the chemical reduction method and sol–gel technique followed by full characterization. SiO(2)@AgNPs were added to the poultry diet at three doses (2, 4, and 8 mg/kg diet). The safety of the oral dietary supplementation was estimated through the evaluation of the growth performance and hematological, biochemical, and oxidative parameters of birds. Moreover, the immunohistochemical examination of all body organs was also performed. Results of this study showed that SiO(2)@AgNPs have no negative effects on the growth performance and hematological, biochemical, and oxidative parameters of birds. Moreover, the immunohistochemical examination revealed the minimum inflammatory reactions and lymphoid depletion under a dose level of 8 mg/kg. In conclusion, SiO(2)@AgNPs could be considered as a promising and safe nano-growth promoter in broilers when added to poultry diet under a dose level of 4 mg/kg diet.
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spelling pubmed-78928422021-02-23 Dietary supplementation of silver-silica nanoparticles promotes histological, immunological, ultrastructural, and performance parameters of broiler chickens Dosoky, Waleed M. Fouda, Moustafa M. G. Alwan, Ali B. Abdelsalam, Nader R. Taha, Ayman E. Ghareeb, Rehab Y. El-Aassar, M. R. Khafaga, Asmaa F. Sci Rep Article Silver nanoparticles (AgNPs) have been used as a promising alternative to antibiotics in poultry feed. In this study, silver-doped silica nanoparticles (SiO(2)@AgNPs) were prepared in powder form, using starch, via the chemical reduction method and sol–gel technique followed by full characterization. SiO(2)@AgNPs were added to the poultry diet at three doses (2, 4, and 8 mg/kg diet). The safety of the oral dietary supplementation was estimated through the evaluation of the growth performance and hematological, biochemical, and oxidative parameters of birds. Moreover, the immunohistochemical examination of all body organs was also performed. Results of this study showed that SiO(2)@AgNPs have no negative effects on the growth performance and hematological, biochemical, and oxidative parameters of birds. Moreover, the immunohistochemical examination revealed the minimum inflammatory reactions and lymphoid depletion under a dose level of 8 mg/kg. In conclusion, SiO(2)@AgNPs could be considered as a promising and safe nano-growth promoter in broilers when added to poultry diet under a dose level of 4 mg/kg diet. Nature Publishing Group UK 2021-02-18 /pmc/articles/PMC7892842/ /pubmed/33603060 http://dx.doi.org/10.1038/s41598-021-83753-5 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Dosoky, Waleed M.
Fouda, Moustafa M. G.
Alwan, Ali B.
Abdelsalam, Nader R.
Taha, Ayman E.
Ghareeb, Rehab Y.
El-Aassar, M. R.
Khafaga, Asmaa F.
Dietary supplementation of silver-silica nanoparticles promotes histological, immunological, ultrastructural, and performance parameters of broiler chickens
title Dietary supplementation of silver-silica nanoparticles promotes histological, immunological, ultrastructural, and performance parameters of broiler chickens
title_full Dietary supplementation of silver-silica nanoparticles promotes histological, immunological, ultrastructural, and performance parameters of broiler chickens
title_fullStr Dietary supplementation of silver-silica nanoparticles promotes histological, immunological, ultrastructural, and performance parameters of broiler chickens
title_full_unstemmed Dietary supplementation of silver-silica nanoparticles promotes histological, immunological, ultrastructural, and performance parameters of broiler chickens
title_short Dietary supplementation of silver-silica nanoparticles promotes histological, immunological, ultrastructural, and performance parameters of broiler chickens
title_sort dietary supplementation of silver-silica nanoparticles promotes histological, immunological, ultrastructural, and performance parameters of broiler chickens
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892842/
https://www.ncbi.nlm.nih.gov/pubmed/33603060
http://dx.doi.org/10.1038/s41598-021-83753-5
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